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ID 52026
フルテキストURL
著者
Asada, Noboru Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Katayama, Yoshio Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Sato, Mari Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Minagawa, Kentaro Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Wakahashi, Kanako Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Kawano, Hiroki Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Kawano, Yuko Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Sada, Akiko Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Ikeda, Kyoji Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology (NCGG)
Matsui, Toshimitsu Hematology, Department of Medicine, Kobe University Graduate School of Medicine
Tanimoto, Mitsune Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録
The bone marrow (BM) niche comprises multiple cell types that regulate hematopoietic stem/progenitor cell (HSPC) migration out of the niche and into the circulation. Here, we demonstrate that osteocytes, the major cellular component of mature bone, are regulators of HSPC egress. Granulocyte colony-stimulating factor (G-CSF), used clinically to mobilize HSPCs, induces changes in the morphology and gene expression of the osteocytic network that precedes changes in osteoblasts. This rapid response is likely under control of the sympathetic nervous system, since osteocytes express the β2-adrenergic receptor and surgical sympathectomy prevents it. Mice with targeted ablation of osteocytes or a disrupted osteocyte network have comparable numbers of HSPCs in the BM but fail to mobilize HSPCs in response to G-CSF. Taken together, these results indicate that the BM/bone niche interface is critically controlled from inside of the bone matrix and establish an important physiological role for skeletal tissues in hematopoietic function.
発行日
2013-06-06
出版物タイトル
Cell Stem Cell
12巻
6号
開始ページ
737
終了ページ
747
資料タイプ
学術雑誌論文
オフィシャル URL
http://dx.doi.org/10.1016/j.stem.2013.05.001
関連URL
http://ousar.lib.okayama-u.ac.jp/metadata/51956
言語
English
著作権者
Copyright © 2013 Elsevier Inc. All rights reserved.
論文のバージョン
author
査読
有り
DOI