start-ver=1.4
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cd-vols=
no-issue=2
article-no=
start-page=73
end-page=78
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2018
dt-pub=20180801
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A new training system for board-certified surgeons
kn-title=外科分野における新しい専門医制度
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
END

start-ver=1.4
cd-journal=joma
no-vol=129
cd-vols=
no-issue=3
article-no=
start-page=179
end-page=184
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=臨床研究中核病院の現状と今後の展望
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=1
ORCID=

affil-num=1
en-affil=Okayama University Hospital Vice Director (Research and International Affairs)
kn-affil=岡山大学病院　副病院長（研究・国際担当）
en-keyword=特定臨床研究
kn-keyword=特定臨床研究
en-keyword=ARO
kn-keyword=ARO
en-keyword=患者申出療養
kn-keyword=患者申出療養
END

start-ver=1.4
cd-journal=joma
no-vol=128
cd-vols=
no-issue=1
article-no=
start-page=27
end-page=32
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=20160401
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Beh?et?s disease complicated by ileocecal and esophageal perforation
kn-title=回盲部潰瘍穿孔，食道潰瘍穿孔をきたした腸管Beh?et 病の1 手術例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=　A 36-year-old Japanese man known to have incomplete Beh?et’s disease (oral aphthous ulcers, genital ulcers, skin lesions, and esophageal and ileocecal ulcers) was admitted to our hospital in January 2011 for abdominal pain. We administered corticosteroids and immunosuppressants. Two months later, we performed an ileocecal resection to control gastrointestinal bleeding from the ileocecal ulcers. High fever persisted after this surgery, and upper gastrointestinal endoscopy demonstrated ulcer penetration between the lower and abdominal esophagus. Eighteen days after the initial ileocecal resection, we performed a lower esophagus resection, gastric tube reconstruction and enterostomy, during which we confirmed a 5-mm-dia. perforated site at the posterior wall of the abdominal esophagus. Postoperative anastomotic leakage and empyema occurred, but they were relieved by thoracic drainage and empyema dissection.
en-copyright=
kn-copyright=

en-aut-name=TsukumoYuta
en-aut-sei=Tsukumo
en-aut-mei=Yuta
kn-aut-name=九十九悠太
kn-aut-sei=九十九
kn-aut-mei=悠太
aut-affil-num=1
ORCID=

en-aut-name=KawamotoKazuyuki
en-aut-sei=Kawamoto
en-aut-mei=Kazuyuki
kn-aut-name=河本和幸
kn-aut-sei=河本
kn-aut-mei=和幸
aut-affil-num=2
ORCID=

en-aut-name=TakagiKosei
en-aut-sei=Takagi
en-aut-mei=Kosei
kn-aut-name=高木弘誠
kn-aut-sei=高木
kn-aut-mei=弘誠
aut-affil-num=3
ORCID=

en-aut-name=ChinKai
en-aut-sei=Chin
en-aut-mei=Kai
kn-aut-name=陳開
kn-aut-sei=陳
kn-aut-mei=開
aut-affil-num=4
ORCID=

en-aut-name=MatsubaYuri
en-aut-sei=Matsuba
en-aut-mei=Yuri
kn-aut-name=松葉優里
kn-aut-sei=松葉
kn-aut-mei=優里
aut-affil-num=5
ORCID=

en-aut-name=NagahisaYoshio
en-aut-sei=Nagahisa
en-aut-mei=Yoshio
kn-aut-name=長久吉雄
kn-aut-sei=長久
kn-aut-mei=吉雄
aut-affil-num=6
ORCID=

en-aut-name=OkabeMichio
en-aut-sei=Okabe
en-aut-mei=Michio
kn-aut-name=岡部道雄
kn-aut-sei=岡部
kn-aut-mei=道雄
aut-affil-num=7
ORCID=

en-aut-name=ShirakawaYasuhiro
en-aut-sei=Shirakawa
en-aut-mei=Yasuhiro
kn-aut-name=白川靖博
kn-aut-sei=白川
kn-aut-mei=靖博
aut-affil-num=8
ORCID=

en-aut-name=ItohTadashi
en-aut-sei=Itoh
en-aut-mei=Tadashi
kn-aut-name=伊藤雅
kn-aut-sei=伊藤
kn-aut-mei=雅
aut-affil-num=9
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=2
en-affil=
kn-affil=倉敷中央病院　消化器外科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=4
en-affil=
kn-affil=倉敷中央病院　消化器外科

affil-num=5
en-affil=
kn-affil=倉敷中央病院　消化器外科

affil-num=6
en-affil=
kn-affil=倉敷中央病院　消化器外科

affil-num=7
en-affil=
kn-affil=倉敷中央病院　消化器外科

affil-num=8
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学

affil-num=9
en-affil=
kn-affil=倉敷中央病院　消化器外科

affil-num=10
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科　消化器外科学
en-keyword=ベーチェット病（Beh?et’s disease）
kn-keyword=ベーチェット病（Beh?et’s disease）
en-keyword=食道（esophagus）
kn-keyword=食道（esophagus）
en-keyword=回盲部（ileocecal）
kn-keyword=回盲部（ileocecal）
en-keyword=穿孔（perforation）
kn-keyword=穿孔（perforation）
en-keyword=手術（surgery）
kn-keyword=手術（surgery）
citation=1) 野上晃司，應田義雄，松本譽之：消化管ベーチェット病の診断と治療．Gastroenterol Endosc (2012) 54，3115-3123．
citation=2) 斎藤和義：腸管Behcet の診療ガイドライン．炎症と免疫 (2014) 22，367-369．
citation=3) Smith JA, Siddiqui D：Intestinal：Beh?et?s disease presenting as a massive acute lower gastrointestinal bleed. Dig Sci (2002) 47，517-521．
citation=4) 押谷伸英，川島大知，稲川　誠，十河光栄，飯室正樹，神野良男，山上博一，濱崎尚子，澤　禎徳，原　順一，中村志郎，松本誉之，他：腸管ベーチェット病及び単純性潰瘍の臨床的検討．日大腸肛門病会誌 (2000) 53，116-122．
citation=5) Yi SW, Cheon JH, Kim JH, Lee SK, Kim TI, Lee YC, Kim WH：The prevalence and clinical characteristics of esophageal involvement in patients with Beh?et?s disease. A single center experience in Korea. J Korean Med Sci (2009) 24， 52-56．
citation=6) Shimizu T, Ehrlich GE, Inaba G, Hayashi K：Beh?et disease (Beh?et syndrome). Semin Arthritis Rheum (1979) 8 ，223-260．
citation=7) Kasahara Y, Tanaka S, Nishino M, Umemura H, Shiraha S, Kuyama T：Intestinal involvement in Beh?et?s disease：review of 136 surgical cases in the Japanese literature. Dis Colon Rectum (1981) 24，103-106．
citation=8) 渡辺　勇：腸管型Behcet 病の病理組織学的研究．順天堂医学(1979) 25，450-473．
citation=9) Morimoto Y, Tanaka Y, Itoh T, Yamamoto S, Kurihara Y, Nishikawa K：Esophagobronchial fistula in a patient with Beh?et?s disease. Report of a case. Surg Today (2005) 35，671-676．
citation=10) Brodie TE, Ochner JL：Beh?et?s syndrome with ulcerative oesophagitis：report of the first case. Thorax (1973) 28，637-640．
citation=11) Parkin JV, Wight DGD：Beh?et?s disease and the alimentary tract. Postgrad Med J (1975) 51，260-264．
citation=12) Lebwohl O, Forde EA, Bardon WE, Morrison S, Challop R：Ulcerative esophagitis and colitis in a pediatric patient with Beh?et?s syndrome. Response to steroid therapy. Am J Gastroenterol (1977) 68，550-555．
citation=13) Levack B, Hanson D：Beh?et?s disease of the esophagus. J Laryngol Otol (1979) 93，99-101．
citation=14) Mori S, Yoshihira A, kawamura H, Takeuchi A, Hashimoto T, Inaba G：Esophageal involvement in Beh?et?s disease. Am J Gastroenterol (1983) 78，548-553．
citation=15) 真田　毅，阿保七三郎，前田清貴，工藤　保，泉　啓一：Beh?et病(不全型) に併発した食道気管支瘻の1 治験例．秋田医学(1986) 13，501-504．
citation=16) 浅岡峰雄，酒井喜正，木村次郎，市原利彦，関　　章，石井正大：ベーチェット病に伴う気管食道瘻の1 手術例．日胸外会誌(1990) 38，155-159．
citation=17) 方堂祐治，鷹取　元，寺島健志，加賀谷尚史：食道胃瘻を合併した腸管ベーチェット病を疑った1 剖検例．Prog Med (2010) 30，2017-2020．
citation=18) Kimura N, Takada K, Murata K, Kohsaka H, Miyasaka N：A case of Beh?et?s disease complicated by carotid-oesophageal fistula. Rheumatology (2014) 53，196-198．
citation=19) Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F, Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, et al.：The 2nd edition of consensus statements for the diagnosis and management of intestinal Beh?et?s disease：indication of anti-TNFαmonoclonal antibodies.J Gastroenterol (2014) 49，156-162．
citation=20) Naganuma M, Iwao Y, Inoue N, Hisamatsu T, Imaeda H, Ishii H, Kanai T, Watanabe M, Hibi T：Analysis of clinical course and long-term prognosis of surgical and nonsurgical patients with intestinal Beh?et?s disease. Am J Gastroenterol (2000) 95，2848-2851．
END

start-ver=1.4
cd-journal=joma
no-vol=127
cd-vols=
no-issue=3
article-no=
start-page=213
end-page=218
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2015
dt-pub=20151201
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case report of giant ectopic pheochromocytoma conversion therapy with radioisotope therapy and chemotherapy followed by curative resection
kn-title=術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected.
 The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs.
 On pathological and immunopathological findings, the tumor was diagnosed as ectopic　pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs.
en-copyright=
kn-copyright=

en-aut-name=YasuiKazuya
en-aut-sei=Yasui
en-aut-mei=Kazuya
kn-aut-name=安井和也
kn-aut-sei=安井
kn-aut-mei=和也
aut-affil-num=1
ORCID=

en-aut-name=UmedaYuzo
en-aut-sei=Umeda
en-aut-mei=Yuzo
kn-aut-name=楳田祐三
kn-aut-sei=楳田
kn-aut-mei=祐三
aut-affil-num=2
ORCID=

en-aut-name=KumanoKenjiro
en-aut-sei=Kumano
en-aut-mei=Kenjiro
kn-aut-name=熊野健二郎
kn-aut-sei=熊野
kn-aut-mei=健二郎
aut-affil-num=3
ORCID=

en-aut-name=TabataMasahiro
en-aut-sei=Tabata
en-aut-mei=Masahiro
kn-aut-name=田端雅弘
kn-aut-sei=田端
kn-aut-mei=雅弘
aut-affil-num=4
ORCID=

en-aut-name=OtsukaFumio
en-aut-sei=Otsuka
en-aut-mei=Fumio
kn-aut-name=大塚文男
kn-aut-sei=大塚
kn-aut-mei=文男
aut-affil-num=5
ORCID=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=6
ORCID=

en-aut-name=FujiwaraToshiyoshi
en-aut-sei=Fujiwara
en-aut-mei=Toshiyoshi
kn-aut-name=藤原俊義
kn-aut-sei=藤原
kn-aut-mei=俊義
aut-affil-num=7
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=2
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=3
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=4
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=5
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=6
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科

affil-num=7
en-affil=
kn-affil=岡山大学大学院医歯薬学総合研究科
en-keyword=異所性褐色細胞腫（ectopic pheochromocytoma）
kn-keyword=異所性褐色細胞腫（ectopic pheochromocytoma）
en-keyword=化学療法（chemo therapy）
kn-keyword=化学療法（chemo therapy）
en-keyword=131I-MIBG
kn-keyword=131I-MIBG
citation=1)柳瀬敏彦 : 副腎ホルモン産生異常 厚生労働省「副腎ホルモン産生異常に関する調査研究班」の研究概要紹介―疫学研究を中心に―. 最新医学 (2012) 67, 1981-1988. 
citation=2)飯原雅季 : 特集【神経内分泌腫瘍に対する治療戦略】副腎. 癌と化学療法 (2009) 36, 1623-1626. 
citation=3)Whalen RK, Althausen AF, Daniels GH : Extra-adrenal pheochromocytoma. J Urol (1992) 147, 1-10. 
citation=4)逢坂公人, 横西哲広, 伊藤悠亮, 小宮 敦, 小林一樹, 酒井直樹, 野口純男, 岸 洋一, 津浦幸夫 : 後腹膜に発生した巨大Paragangliomaの1例. 泌尿器科紀要 (2010) 56, 377-380. 
citation=5)竹原浩介, 酒井英樹 : 褐色細胞腫. 内分泌甲状腺外会誌 (2014) 31, 175-179. 
citation=6)高川 亮, 大島 貴, 羽鳥慎祐, 國崎主税, 池 秀之, 今田敏夫, 上條聖子 : 術中高血圧をきたした後腹膜パラガングリオーマの1例. 日臨外会誌 (2004) 65, 1695-1700. 
citation=7)Adjalle R, Plouin PF, Pacak K, Lehnert H : Treatment of malignant pheochromocytoma. Horm Metab Res (2009) 41, 687-696. 
citation=8)Goldstein RE, O'Neill JA Jr, Holcomb GW 3rd, Morgan WM 3rd, Neblett WW 3rd, Oates JA, Brown N, Nadeau J, Smith B, Page DL, Abumrad NN, Scott HW Jr : Clinical experience over 48 years with pheochromocytoma. Ann Surg (1999) 229, 755-756. 
citation=9)近藤昭宏, 大谷 剛, 森 誠治, 若林久男, 岡田節雄, 前田 肇 : von Recklinghausen病に合併した異所性褐色細胞腫の1例. 日臨外会誌 (2003) 64, 3163-3166. 
citation=10)下稲葉耕生, 川原和也, 中条政敬 : 異所性褐色細胞腫の1例. 泌尿器科 (1986) 40, 751-753. 
citation=11)Sisson JC, Frager MS, Valk TW, Gross MD, Swanson DP, Wieland DM, Tobes MC, Beierwaltes WH, Thompson NW : Scintigraphic localization of pheochromocytoma. N Engl J Med (1981) 305, 12-17. 
citation=12)Shapiro B, Copp JE, Sisson JC, Eyre PL, Wallis J, Beierwaltes WH : Iodine-131 metaiodobenzylguanidine for the locating of suspected pheochromocytoma : experience in 400 cases. J Nucl Med (1985) 26, 576-585. 
citation=13)伊夫貴直和, 小村和正, 小山耕平, 稲元輝生, 瀬川直樹, 谷本啓爾, 辻 求, 東 治人, 勝岡洋治 : 術前多剤併用化学療法 (CVD療法) が有用であった膀胱褐色細胞腫の1例. 泌尿器科紀要 (2009) 55, 765-768. 
citation=14)亀高 尚, 牧野裕庸, 石川智啓, 畠田和嘉, 東谷浩一, 長谷川章雄 : 超巨大後腹膜悪性Paragangliomaの1切除例. 癌と化学療法 (2013) 40, 2460-2462. 
citation=15)Scott HW Jr, Reynolds V, Green N, Page D, Oates JA, Robertson D, Roberts S : Clinical experience with malignant pheochromocytomas. Surg Gynecol Obstet (1982) 154, 801-818. 
citation=16)Thompson LD, Young WF, Kawashima A, Komminoth P, Tischler AS : Malignant adrenal phaeochromocytoma ; in WHO classification of tumours : pathology and genetics-tumours of endocrine organs, De Lellis RA, Lloyd RV, Heitz PU, Eng C (eds), IARC, Lyon (2004) pp147-150. 
citation=17)Averbuch SD, Steakley CS, Young RC, Gelmann EP, Goldstein DS, Stull R, Keiser HR : Malignant pheochromocytoma : effective treatment with a combination of cyclophosphamide, vincristine, and dacarbazine. Ann Intern Med (1998) 109, 267-273. 
citation=18)Huang H, Abraham J, Hung E, Averbuch S, Merino M, Steinberg SM, Pacak K, Fojo T : Treatment of malignant pheochromocytoma/paraganglioma with　cyclophosphamide, vincristine, and dacarbazine : recommendation from a 22-year follow-up of 18 patients. Cancer (2008) 113, 2020-2028. 
citation=19)成瀬光栄, 田辺晶代, 立木美香, 難波多挙, 中尾佳奈子, 津曲 綾, 臼井 健, 田上哲也, 島津 章 : 悪性褐色細胞腫の診断と治療. 日内会誌 (2012) 101, 2330-2338. 
citation=20)Shapiro B : Summary, conclusions, and future directions of [131I]metaiodobenzylguanidine therapy in the treatment of neural crest tumors. J Nucl Biol Med (1991) 35, 357-363. 
citation=21)佐藤康幸, 舟橋啓臣, 今井常夫 : 多発性骨転移を伴う悪性褐色細胞腫症例に対する集学的治療. 日臨外会誌 (1993) 54, 2911-2915.
END