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ID 13826
Eprint ID
13826
フルテキストURL
Thumnail 106_131.pdf 713 KB
タイトル(別表記)
The pathogenesis of iron deficiency anemia : Experimental iron deficiency derived from renal injury induced by Puromycin aminonucleoside
著者
藤井 総一郎 岡山大学医学部第二内科学教室
抄録
To clarify the pathogenesis of idiopathic iron deficiency anemia, small amounts of Puromycin aminonucleoside (PAN) which is known to be nephrotoxic, was administered repeatedly to induce continuous urinary iron excretion in rats. Urinary iron, serum iron, stored iron content and hemoglobin concentration were investigated. Urinary iron excretion was increased by PAN administration along with increased excretion of urinary transferrin. Consequently, a large amount of urinary iron seemed to be was observed with respect to continuous urinary iron excretion, manifesting normocytic hypochromic anemia at 13th week. These results suggest that prolonged loss of small amounts of iron through the urinary tract causes iron deficiency without alinical manifestation of ranal failure.
キーワード
urinary iron
renal injury
iron deficiency anemia
Puromycin aminonucleoside
rat
備考
原著
発行日
1994-02
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
131
終了ページ
143
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/1-2/106_1-2_131/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma