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ID 40767
フルテキストURL
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タイトル(別表記)
Studies of iron metabolism of the lung Part 2. An electron microscopic study of ferritin synthesis in alveolar macrophages
著者
藤原 寛太 岡山大学医学部第二内科学教室
抄録
In order to clarify the role of alveolar macrophages (alv Mφ) in the iron metabolism of the lung, ultrastructural findings of cells obtained by bronchoalveolar lavage were studied by transmission electron microscopy in rats after inhalation of saccharated iron oxide and welding fumes as well as a patient with welder's lung. Alv Mφ of rats which had inhaled saccharated iron oxide formed phagosomes and secondary lysosomes 4 hours after inhalation. The first day after inhalation, many ferritin particles were seen in cytosol and formed a diffuse patterns; 19% of alv Mφ had ferritin particles in a paracrystalin arrangement in the secondary lysosomes. Electron micrographs of alv Mφ at 3, 6, 14, and 28 days after inhalation showed an increase of the cells with ferritin particles. Alv Mφ of rats which had inhaled welding fumes phagocytized those iron particles and also synthesized ferritin particles in the cytosol and secondary lysosomes 6 days after inhalation. Numerous ferritin particles were seen in the cytosol and secondary lysosomes of alv Mφ from a patient with welder's lung as well. These results suggest that inhaled iron was phagocytized by alv Mφ and stored in the cytosol by binding with apoferritin which was synthesized by the ribosomes.
キーワード
フェリチン
担鉄肺胞マクロファージ
溶接工肺
ラット
透過型電顕
発行日
1989-08-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
101巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
733
終了ページ
742
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/101/7-8/101_7-8_733/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma