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ID 40766
フルテキストURL
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タイトル(別表記)
Studies of iron metabolism of the lung Part 1. Influence of inhaled iron on iron metabolism of an experimental welder's lung
著者
藤原 寛太 岡山大学医学部第二内科学教室
抄録
In order to clarify the mechanism of elevated iron stores in welder's lungs, the cellular contents of bronchoalveolar lavage (BAL) fluid, the serum iron, total iron binding capacity, liver non-hemin iron and histological findings were examined in experiments using Wister rats exposed to inhalation of welding fumes for 4, 8, Total cell counts, the percentage of neutrophils and iron laden alveolar macrophages in the BAL fluid increased after continuous inhalation, but they were decreased 3 months after inhalation. Serum iron, transferrin saturation, and liver non-hemin iron in rats exposed to inhalation for 8 and 12 weeks were significantly elevated (p<0.01). Iron stores of rats 3 months after inhalation were elevated more than levels 1 week after inhalation. Histological findings in the lung showed a slight thickening of alveolar wall with cellular infiltration. Iron was deposited predominantly in alveolar macrophages of the alveolar space and in connective tissue macrophages. Iron deposition was also seen in the red pulp of the spleen after inhalation. These data suggest that iron was highly stored in the whole body of patients with welder's lung, and that alveolar macrophages play an important role in the iron metabolism of the lung.
キーワード
溶接フューム
気管支肺胞洗浄
溶接工肺
鉄過剰症
ラット
発行日
1989-08-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
101巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
723
終了ページ
732
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/101/7-8/101_7-8_723/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma