著者 Fujita, Hirofumi| Shiosaka, Masahiko| Ogino, Tetsuya| Okimura, Yuya| Utsumi, Toshihiko| Sato, Eisuke F.| Akagi, Reiko| Inoue, Masayasu| Utsumi, Kozo| Sasaki, Junzo|
発行日 2008-06-23
出版物タイトル Brain Research
1206巻
資料タイプ 学術雑誌論文
JaLCDOI 10.18926/AMO/30712
フルテキストURL fulltext.pdf
著者 Omori, Masako| Toyoda, Hiroshi| Hirai, Takeshi| Ogino, Tetsuya| Okada, Shigeru|
抄録 Angiomyofibroblastoma is a rare, usually small benign mesenchymal tumor that occurs in vulvar lesions of premenopausal women. A case of angiomyofibroblastoma that arose as a unique pedunculated and particularly large mass in the left vulva of a 48-year-old woman is presented herein. The patient had been aware of a gradually enlarged mass of 7 years duration without any other gynecological symptoms or signs. The maximum dimension of the tumor measured 11 cm. The resected tumor was well circumscribed with a bulging and glistening cut surface. Histological examination revealed an admixture of irregularly distributed hypercellular and hypocellular areas with spindled, plump spindled, or plasmacytoid stromal cells and abundant venular or capillary-sized vessels. Stromal cells characteristically cluster around delicate vessels within an edematous to collagenous matrix. In the present case, intralesional adipose tissue was present throughout the tumor. There was no significant nuclear atypia, and mitotic figures were very sparse. There was little stromal mucin throughout the tumor. Immunohistochemically, the stromal cells were characterized by strong reactivity for vimentin and CD34, with focal reactivity for desmin and alpha smooth muscle actin. Both estrogen and progesterone receptors were diffusely expressed in the stromal cells. These histological findings are consistent with angiomyofibroblastoma and support the hypothesis that angiomyofibroblastoma originates from perivascular stem cells with a capacity for myofibroblastic and fatty differentiation.
キーワード angiomyofibroblastoma vulva adipose tissue pedunculated mass
Amo Type Article
発行日 2006-08
出版物タイトル Acta Medica Okayama
60巻
4号
出版者 Okayama University Medical School
開始ページ 237
終了ページ 242
ISSN 0386-300X
NCID AA00508441
資料タイプ 学術雑誌論文
言語 English
論文のバージョン publisher
査読 有り
PubMed ID 16943862
Web of Sience KeyUT 000239911100006
著者 寳迫 睦美| 荻野 哲也| 岡田 茂|
発行日 2006-01-04
出版物タイトル 岡山医学会雑誌
117巻
3号
資料タイプ 学術雑誌論文
著者 荻野 哲也|
発行日 1988-03-28
出版物タイトル
資料タイプ 学位論文