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ID 18061
Eprint ID
18061
フルテキストURL
Thumnail 79_637.pdf 3.2 MB
タイトル(別表記)
Histochemical Studies of Hydrolytic Enzymes and Dehydrogenases in the Human Gastric Cancers Part Ⅰ. Analysis from the Histological Features and the Grade of Advancement
著者
竹内 鬼三郎 岡山大学医学部第1外科教室
抄録
Histochemical studies of five hydrolytic enzymes, i. e. alkaline phosphatase, acid phosphatase, beta esterase, beta-glucuronidase, and leucine aminopeptidase and eight dehydrogenases, i. e. lactic, succinic, malic, alpha-glycerophosphate, glutamic, beta-hydroxybutyric, glucose-6-phosphate, and isocitric dehydrogenase were carried out in the gastric cancers removed from 100 patients. Enzyme activities were compared with the histological features of stomach cancers in each patient and the grade of its advancement. Histological analysis of stomach cancer was followed by the classification established in 1962 by the Japanese Pathological Society. And the grade of advancement was judged by the criteria eatablished by the Japanese Reserch Society for Gastric Cancer. As a whole, the poorer differentiated cancer cells showed the weaker enzyme activites than the well differentiated ones. However, no correlations were observed between enzyme activities and the grade of infiltration by cancer cells. Generally enzyme activities of carcinoma simplex were weaker than those of adenocarcinom and scirrhous carcinoma showed slightlly weaker activity than carcinoma simplex. According to the classification of Borrmann, enzyme activites of infiltrative types were weaker than those in localized types. Lactic dehydrogenase showed the strongest staining intensity in all of the enzymes. The activity was observed in hydrolytic enzymes of carcinoma cells in the following desending order: beta-glucuronidase, beta-esterase, acid phosphatase, leucine aminopeptidase and alkaline phosphatase, while in that of stromal elements : beta-glucuronidase, acid phospbaase, beta-esterase, alkaline phosphatase and leucine aminopeptidase. The activity of dehydrogenases of carcinoma cells was in the following desending order: lactic, malic, glucose-6-phoshate, isocitric, succinic, alpha-glycerophosphate, glutamic and beta-hydroxybutyric dehydrogenase, and in that of stromal elements : lactic, malic, succinic, alpha-glycerophosphate which was similar to glutamic, beta-hydroxybutyric similar to glucose-6-phosphate and isocitric dehydrogenase. There was a tendency that the cancer tissues obtained from the patients of more advanced stage showed the stronger activity of enzymes than that of early stage ones.
発行日
1967-08-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
79巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
637
終了ページ
654
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/79/7-8/79_7-8_637/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma