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ID 14612
Eprint ID
14612
フルテキストURL
Thumnail 078_1297.pdf 3.12 MB
タイトル(別表記)
A Therapeutic Use of a-Mercaptopropionylglycine (Thiola) as a Chelating Agent for Excess Tissue Iron in the Liver
著者
太田 康幸 岡山大学医学部小坂内科
福島 功 岡山大学医学部小坂内科
折免 昭雄 岡山大学医学部小坂内科
抄録
A comparative study of α-mercaptopropionylglycine (α-M P G) as a therapeutic chelating agent for excess tissue iron in the liver with commercially available drugs was undertaken. The drugs used for the compari on were B A L, penicillamine, sodium dithiocarbamate and desferrioxamine B. The materials studied were 11 cases of moderate to severe hepatic hemosiderosis, either primary or secondary, diagnosed with needle liver biopsy specimens. The results were as follows: 1) The decrease of serum iron, disappearance or reduction of stainable tissue iron in the liver, depigmentation of the skin were induced by parenteral or oral administration of α-M P G at the daily dosis of 200 to 450 mg for 2 to 6 months. The phenomena were explained as the results of a chelating effect of α-M P G on excess tissue iron in the liver. 2) No significant effect on essential serum electrolyte such as potassium, calcium was observed during the α-M P G administration. 3) No undesirable side effect was noted, therefore, a prolonged administration was practicable. 4) Iron excretion into the urine was less intense than that with dithiocarbamate, however, it was more intense than that with penicillamine. On the other hand, iron excretion into the feces was observed in the decreasing order with dithiocarbamate, desferrioxamine B, penicillamime, and α-M P G. The daily excretion of iron into urine amounted 2 to 4 mg with α-M P G.
発行日
1966-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
78巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1297
終了ページ
1305
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/78/11-12/78_11-12_1297/_article/-char/ja/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma