岡山医学会 Acta Medica Okayama 0030-1558 127 3 2015 術前内照射および化学療法が著効し,根治切除し得た巨大異所性褐色細胞腫の1例 213 218 EN Kazuya Yasui Yuzo Umeda Kenjiro Kumano Masahiro Tabata Fumio Otsuka Takahito Yagi Toshiyoshi Fujiwara A 46-year-old man was found to be positive for occult blood at a medical checkup and was revealed to have a 14-cm tumor on the right side of abdominal aorta by a subsequent abdominal CT scan. The endocrinology laboratory data showed elevations in the levels of serum noradrenaline, and ectopic pheochromocytoma was suspected. The tumor was compressing the inferior vena cava and portal vein, the superior mesenteric artery and the pancreas. Since it would be difficult to cure by operation, neoadjuvant therapy was started using radioisotope therapy by I-131 metaiodobenzylguanidine (131I-MIBG) and chemotherapy (CVD therapy ; cyclophosphamide, vincristine, dacarbazine). He was treated with three courses of radioisotope therapy and 16 courses of chemotherapy, which significantly reduced the tumor size. This made radical resection possible ; we were able to avoid the merger excision of great vessels and other organs. On pathological and immunopathological findings, the tumor was diagnosed as ectopic　pheochromocytoma. Regarding the safety and curability of the treatment, neoadjuvant therapy may be useful in treating very large tumors that show invasion of other organs. No potential conflict of interest relevant to this article was reported.

Acta Medica Okayama 2017 Pretreatment of donor islets with papain improves allograft survival without systemic immunosuppression in mice EN Kenjiro Kumano Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University No potential conflict of interest relevant to this article was reported.