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ID 15871
Eprint ID
15871
フルテキストURL
Thumnail 99_169.pdf 1.09 MB
タイトル(別表記)
Experimental study of the hepatic accumulation of the immune complex and its hepatocytotoxity
著者
渡辺 正博 岡山大学医学部第一内科学教室
抄録
It was studied whether IgG-immune complexes were taken up by liver parenchymal cells and whether liver injury was induced by the immune complexes. When asialoorosomucoid, orosomucoid and human serum albumin immune complexes at various antigen-antibody ratios were infused into the portal vein of rats, the antibody-excess immune complexes were partly taken up by liver parenchymal cells via the asialoglycoprotein receptor. However, liver injury was not caused by the immune complexes. These observations suggest that 1) immune complexes at certain antigen-antibody ratios bind to the asialogycoprotein receptor, 2) immune complexes bound to the asialoglycoprotein receptor do not activate the complement system and 3) a transient increase in plasma immune complexes does not induce liver injury.
キーワード
免疫複合体
アシアロ糖蛋白質受容体
肝障害
発行日
1987-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
169
終了ページ
178
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/1-2/99_1-2_169/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma