このエントリーをはてなブックマークに追加
ID 16394
Eprint ID
16394
フルテキストURL
Thumnail 95_1029.pdf 637 KB
タイトル(別表記)
Studies on lipid metabolism of cholesterol fed rats Part 2 Metabolism of liver mitochondria
著者
渕本 武文 岡山大学医学部第2内科
抄録
This paper describes the fatty acid metabolism of liver mitochondria as determined by I-(14)C acetate incorporation in rats which were fed a diet supplemented with cholesterol, cholic acid and stearic acid (CCS). In liver mitochondria, fatty acid biosynthesis was considered to be the main part of lipid biosynthesis and cholesterol biosynthesis to be negligible. Fatty acid biosynthesis of the liver mitochondria did not change by the addition of ATP and NADH, but decreased by the addition of palmitoyl carnitine. The recovery of (14)CO(2) from I-(14)C acetate in the mitochondria was significantly increased by the addition of ATP. The CCS feeding markedly elevated cholesterol and phospholipid levels. As for the serum fatty acid composition, stearic acid and oleic acid increased, and linoleic acid and arachidonic acid decreased. On the other hand, in liver mitochondria, oleic acid increased and arachidonic acid decreased. The CCS feeding had a tendency to increase fatty acid biosynthesis of liver mitochondria although there was no significant difference in the pattern of each fatty acid biosynthesis between the CCS and control groups.
キーワード
肝ミトコンドリア
脂肪酸代謝
コレステロール負荷ラット
発行日
1983-10-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1029
終了ページ
1040
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/9-10/95_9-10_1029/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma