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ID 32871
JaLCDOI
フルテキストURL
著者
Ogino, Keiki Okayama University
Wang, Da-Hong Okayama University
抄録
Oxidative/nitrosative stress is responsible for a variety of degenerative processes in some human diseases. Measurement of oxidatively/nitrosatively modified DNA, proteins, lipids, and sugars in biological samples has been expected to detect appropriate biomarkers for diseases in which reactive oxygen/nitrogen species are involved. Recently, the application of these biomarkers to epidemiological studies has resulted in a new discipline, molecular epidemiology, which provides the opportunity for better understanding of their causal relation with disease outcomes in a population level. In this brief review, we cover some specific biomarkers of oxidative/nitrosative stress with regard to the commonly used analytical methods for these biomarkers, their integration with epidemiology, and their application in antioxidant intervention trials, with an emphasis on those applicable to human studies and their potentialities for disease prevention.
キーワード
biomarker
oxidative/nitrosative stress
molecular epidemiology
disease prevention
Amo Type
Review
発行日
2007-08
出版物タイトル
Acta Medica Okayama
61巻
4号
出版者
Okayama University Medical School
開始ページ
181
終了ページ
189
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT