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ID 32805
JaLCDOI
フルテキストURL
著者
Matsuka, Yoko Okayama University
Wang, Da-Hong Okayama University
Suganuma, Narufumi Okayama Univresity
Imai, Kaori Okayama University
Ikeda, Satoru Okayama University
Taketa, Kazuhisa Okayama University
Kira, Shohei Okayama University
抄録

We studied the association of gamma-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.

キーワード
gamma-glutamyltransferase(GGT)
daily alcohol consumption
good responder and poor responder
Amo Type
Article
発行日
2003-08
出版物タイトル
Acta Medica Okayama
57巻
4号
出版者
Okayama University Medical School
開始ページ
171
終了ページ
178
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT