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ID 30941
JaLCDOI
フルテキストURL
著者
Ota, Kei Department of Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Mizuno, Toshihide Department of Artificial Organs, National Cardiovascular Center Research Institute
Tatsumi, Eisuke Department of Artificial Organs, National Cardiovascular Center Research Institute
Katagiri, Nobumasa Department of Artificial Organs, National Cardiovascular Center Research Institute
Taenaka, Yoshiyuki Department of Artificial Organs, National Cardiovascular Center Research Institute
Ishizuka, Takanobu Research and Development Center, Terumo Corporation
Ogata, Yoshitaka Research and Development Center, Terumo Corporation
Ujike, Yoshihito Department of Emergency Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
抄録

Percutaneous cardiopulmonary support (PCPS) has been applied for cardiopulmonary arrest (CPA). We have developed a novel method of cardiopulmonary resuscitation using PCPS combined with liposome-encapsulated hemoglobin (TRM645) to improve oxygen delivery to vital organs. Ventricular fibrillation was electrically induced to an adult goat for 10 min. Next, PCPS (30 ml/kg/min, V/Q: 1) was performed for 20 min. Then, external defibrillation was attempted and observed for 120 min. The TRM group (n5) was filled with 300 mL of TRM645 for the PCPS circuit. The control group (n5) was filled with the same volume of saline. The delivery of oxygen (DO2) and oxygen consumption (VO2) decreased markedly by PCPS after CPA, compared to the preoperative values. DO2 was kept at a constant level during PCPS in both groups, but VO2 slowly decreased at 5, 10, and 15 min of PCPS in the control groups, demonstrating that systemic oxygen metabolism decreased with time. In contrast, the decreases in VO2 were small in the TRM group at 5, 10, and 15 min of PCPS, demonstrating that TRM645 continuously maintained systemic oxygen consumption even at a low flow rate. AST and LDH in the TRM group were lower than the control. There were significant differences at 120 min after the restoration of spontaneous circulation (p<0.05).

キーワード
percutaneous cardiopulmonary support
liposome-encapsulated hemoglobin
cardiopulmonary resuscitation
Amo Type
Original Article
発行日
2008-08
出版物タイトル
Acta Medica Okayama
62巻
4号
出版者
Okayama University Medical School
開始ページ
235
終了ページ
239
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT