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ID 14442
Eprint ID
14442
フルテキストURL
Thumnail 103_1.pdf 10.3 MB
タイトル(別表記)
Experimental study of central nervous system stimulation on pain relief -Effect of cerebral cortical stimulation on neuronal activity of subnucleus caudalis of spinal trigeminal nucleus in cat-
著者
正岡 哲也 岡山大学医学部脳神経外科学教室
抄録
The effect of electrical stimulation of cerebral cortex on neuronal activity in the subnucleus caudalis of the spinal trigeminal nucleus (STNcd) was examined electrophysiologically in the cat. The nociceptive neuronal firing in the STNcd was suppressed by electrical stimulation of contralateral cerebral cortex (primary motor : Msl or primary somatosensory : Sml cortical area.) The high amplitude spontaneous and continuous neuronal hyperactivity (deafferentation hyperactivity : DH), which was provoked in the left STNcd after complete ablation of left Gasserian ganglion, was conspicuously suppressed by the electrical stimulation of the cerebral cortex (Msl stimulation : 5/36 ; Sml stimulation : 12/36). Almost all neurons (nociceptive and DH neuron), the neuronal activity of which was suppressed by electrical stimulation of cerebral cortex, were located in the dorsal and ventral reticular subnuclei of STNcd. On the other hand, the injection of wheat germ agglutinin labeling horseradish peroxidase into the cerebral cortex (Msl) demonstrated that the efferent fibers passed through the internal capsule (IC) and projected directly to the dorsal and ventral reticular subnuclei of the STNcd of the contralateral side. This study suggested that the neuronal firing in STNcd (nociceptive neuronal firing and DH) was suppressed by stimulation of the inhibitory efferent fibers from the cerebral cortex to STNcd by electrical stimulation of IC and cerebral cortex.
キーワード
intractale pain
deafferentation hyperactivity
deafferented pain
cerebral cortex
internal capsule
備考
原著
発行日
1991
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
103巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1
終了ページ
18
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/103/1-2/103_1-2_1/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma