タイトル(別表記) A patient with primary malignant melanoma of the esophagus who underwent esophagectomy
フルテキストURL 126_45.pdf
著者 前田 直見| 白川 靖博| 國府島 健| 大原 利章| 田邊 俊輔| 野間 和広| 櫻間 教文| 藤原 俊義|
抄録  We report the case of a 61-old-man with a primary malignant melanoma of the esophagus, an extremely rare and highly aggressive malignancy. He presented with dysphagia, and we performed an upper gastrointestinal endoscopy that detected a tumor in the thoracic part of the esophagus. The biopsy showed malignant melanoma. PET/CT, endoscopy and an esophagogram showed that a 70-mm scaled type 2+1 tumor in the thoracic esophagus and no metastases. We diagnosed a cT3cN0cM0 cStage II tumor. We then performed a subtotal esophagectomy with two-field lymph node dissection and esophagogastrostomy via a retrosternal route. The pathological examination of the resected specimens confirmed that the type 2+1 tumor was PMME (pT2N0M0 pStage II). We administered six courses of postoperative adjuvant chemotherapy with dacarbazine, and the patient has had no recurrence for 17 months after the surgery.
キーワード 食道(esophagus) 悪性黒色腫(malignant melanoma)
備考 症例報告 (Case Reports)
出版物タイトル 岡山医学会雑誌
発行日 2014-04-01
126巻
1号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 45
終了ページ 48
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.45
Sort Key 9
Eprints Journal Name joma
参考文献 1) Tachimori Y, Ozawa S, Fujishiro M, Matsubara H, Numasaki H, Oyama T, Shinoda M, Toh Y, Udagawa H, Uno T : Comprehensive registry of esophageal cancer in Japan, 2005. Esophagus (2014) 11, 1-20. 2) 山口智弘, 塩飽保博, 小出一真, 栗岡英明, 信谷健太郎, 船津英司, 久津見弘, 藤本荘太郎, 細川洋平 : 食道原発悪性黒色腫の1例と本邦報告例(193例)の検討. 日消誌(2004)10, 1087-1094. 3) 庄村 遊, 村林絋二, 林 仁庸, 中野英明, 上原伸一, 楠田 司, 大橋直樹, 武藤利茂 : 食道原発悪性黒色腫の1例. 日臨外会誌(1995)56, 544-548. 4) Allen AC, Spittz S : Malignant melanoma. A clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer (1953) 6, 1-45. 5) Yonal O, Ibrisim D, Songur Y, Cakaloglu Y, Tuncer K, Kirimlioglu H, Ozdil S : Primary malignant melanoma of the esophagus. Case Rep Gastroenterol (2013) 7, 272-276. 6) Sabanathan S, Eng J, Pradhan GN : Primary malignant melanoma of the esophagus. Am J Gastroenterol (1989) 84, 1475-1481. 7) Volpin E, Sauvanet A, Belghiti J : Primary malignant melanoma of the esophagus : a case report and review of the literature. Dis Esophagus (2002) 15, 244-249. 8) Bisceglia M, Perri F, Tucci A, Tardio M, Panniello G, Vita G, Pasquinelli G : Primary malignant melanoma of the esophagus. Adv Anat Pathol (2011) 18, 235-252. 9) Morita FH, Ribeiro U Jr, Sallum RA, Tacconi MR, Takeda FR, da Rocha JR, Ligabó Gde S, de Melo ES, Pollara WM, Cecconello I : Primary malignant melanoma of the esophagus : a rare and aggressive disease. World J Surg Oncol (2013) 11, 210. 10) Mukaiya M, Hirata K, Tarumi K, Takashima T, Hata F, Denno R, Koito K, Takahashi S, Satoh M : Surgical treatment for recurrent tumors of primary malignant melanoma of the esophagus : a case report and review of the literature. Hepatogastroenterology (1999) 46, 295-298. 11) Iwanuma Y, Tomita N, Amano T, Isayama F, Tsurumaru M, Hayashi T, Kajiyama Y : Current status of primary malignant melanoma of the esophagus : clinical features, pathology, management and prognosis. J Gastroenterol (2012) 47, 21-28.
タイトル(別表記) Complete response of primary esophageal endocrine cell carcinoma resected after neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil
フルテキストURL 126_39.pdf
著者 前田 直見| 白川 靖博| 國府島 健| 大原 利章| 田邊 俊輔| 野間 和広| 櫻間 教文| 藤原 俊義|
抄録  Esophageal endocrine cell carcinoma is extremely rare. We report a case of esophageal endocrine cell carcinoma showing histological complete response to neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (DCF). A 66-year-old man had been experiencing epigastralgia, and a type 2 tumor in the thoracic part of esophagus was detected by upper endoscopy. The biopsy showed endocrine cell carcinoma. PET/CT, endoscopy and an esophagogram showed that the patient had a 70-mm scaled type 2 tumor in the middle thoracic esophagus, and they also revealed lymph node metastases (no. 106recR). We diagnosed a cT3cN1cM0 cStage III tumor. With two courses of DCF treatment, both the primary tumor and lymph node metastases showed a partial response. We performed a subtotal esophagectomy with three-field lymph node dissection. The pathological examination of the resected specimens revealed no malignant cells in the esophagus or lymph nodes, and we concluded that the pathological effect of the DCF treatment was Grade 3.
キーワード 食道癌(esophageal cancer) 内分泌細胞癌(endocrine cell carcinoma) DCF療法(DCF treatment)
備考 症例報告 (Case Reports)
出版物タイトル 岡山医学会雑誌
発行日 2014-04-01
126巻
1号
出版者 岡山医学会
出版者(別表記) Okayama Medical Association
開始ページ 39
終了ページ 43
ISSN 0030-1558
NCID AN00032489
資料タイプ 学術雑誌論文
関連URL http://www.okayama-u.ac.jp/user/oma/
言語 Japanese
著作権者 Copyright (c) 2014 岡山医学会
論文のバージョン publisher
査読 有り
DOI 10.4044/joma.126.39
Sort Key 8
Eprints Journal Name joma
参考文献 1) Ozawa S, Tachimori Y, Baba H, Fujishiro M, Matsubara H, Numasaki H, Oyama T, Shinoda M, Takeuchi H, Tanaka O, Teshima T, Udagawa H, et al. : Comprehensive registry of esophageal cancer in Japan, 2003. Esophagus (2011) 8, 9-29. 2) Wu Z, Ma JY, Yang JJ, Zhao YF, Zhang SF : Primary small cell carcinoma of esophagus : report of 9 cases and review of literature. World J Gastroenterol (2004) 10, 3680-3682. 3) Hosokawa A, Shimada Y, Matsumura Y, Yamada Y, Muro K, Hamaguchi T, Igaki H, Tachimori Y, Kato H, Shirao K : Small cell carcinoma of the esophagus. Analysis of 14 cases and literature review. Hepatogastroenterology (2005) 52, 1738-1741. 4) Ohmura Y, Takiyama W, Mandai K, Doi T, Nishikawa Y : Small cell carcinoma of the esophagus : a case report. Jpn J Clin Oncol (1997) 27, 95-100. 5) Koide N, Hiraguri M, Kishimoto K, Nakamura T, Adachi W, Miyabayashi H, Terai N, Amano J : Small cell carcinoma of the esophagus with reference to alternating multiagent chemotherapy : report of two cases. Surg Today (2003) 33, 294-298. 6) 杉浦功一, 小澤壯治, 北川雄光, 岡本信彦, 清水芳政, 矢野和仁, 北島政樹 : 食道小細胞癌の1切除例と文献報告例の検討. 日消外会誌(2004)37, 123-129. 7) 橋田秀明, 小室一輝, 岩代 望, 大原正範, 北畠滋郎, 近藤 哲 : 手術と化学療法により長期無再発生存中の食道小細胞癌の1例. 日臨外会誌(2007)68, 1932-1936. 8) Yamashita H, Nakagawa K, Asari T, Murakami N, Igaki H, Okuma K, Ohtomo K : Concurrent chemoradiation alone with curative intent for limited-disease small-cell esophageal cancer in nine Japanese patients. Dis Esophagus (2009) 22, 113-118. 9) Atsumi K, Shioyama Y, Nomoto S, Ohga S, Toba T, Sasaki T, Kunitake N, YoshitakeT, Nakamura K, Honda H : Chemoradiation for small cell esophageal carcinoma : report of 11 cases from multi-instruction experience. J Radiat Res (2010) 51, 15-20. 10) 後藤利博, 渡部宏嗣, 川上高幸, 渡邊雅史, 中野健太郎, 高井敦子, 北澤絵里子, 佐藤新平, 田島康夫, 水口國雄, 菊池健太郎, 宮川 浩 : イリノテカンとシスプラチンの併用化学療法が著効した進行食道小細胞癌の1例. 日消誌(2007)104, 1204-1211. 11) 工藤啓介, 土居浩一, 緒方健一, 平野祐一, 大地哲史 : 集学的治療により長期生存を得た食道小細胞癌の1例. 癌と化療(2010)37, 2403-2405. 12) 佐野 淳, 菊池順子, 小林義輝, 田口 洋, 横山宗伯 : 食道内分泌細胞癌の1切除例. 日消外会誌(2008)41, 1898-1903. 13) 柴田智隆, 片田夏也, 根本昌之, 三重野浩朗, 山下継史, 桜本信一, 菊池史郎, 渡邊昌彦 : 切除可能食道癌に対する術前補助化学療法-JCOG9907からDCF療法へ-. 日外科系連会誌(2012)37, 680-685.