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ID 17673
Eprint ID
17673
フルテキストURL
Thumnail 83_273.pdf 1.11 MB
タイトル(別表記)
Studies on Agricultural Organofluoride Poisoning Part Ⅰ Experimental and clinical studies on organofluoride poisoning with emphasis on treatment
著者
橋田 邦夫 岡山大学医学部平木内科
抄録
Treatment experiments and blood sugar determinations were carried out on organofluoride-intoxicated animals and the results were as follows. 1. FAM (monofluoroacetamide)-intoxicated rats were treated with various acetyl radical transferring compounds of which acetamide was found to be most effective and resulted in 100% recovery of the animals treated. Treatment with ethanol monoacetin, and glucose led to the prolongation of survival times of the intoxicated rats. Some increases of the survival times and anticonvulsive effects were obtained also by the use of phenobarbital and procainamide. 2. Administration of acetamide and procainamide to FAM-intoxicated rabbits resulted in approximately twice as longer survival times as those of the controls. 3. FAM administered rats showed a general tendency to low blood sugar levels, and the more the dosage of FAM was given, the greater the degree of hypoglycemia was observed. The maximum decrease was noted in the midst of or before and after convulsions of the administered rats. Methylparathion and Endrin administered rats, on the contrary, indicated increased levels of blood sugars. These observations suggest that determination of blood sugar levels can be a clue to differentiating organofluoride-intoxication from organic phosphate and chloride (especially Endrin)-intoxications which occur frequently in Japan. And this point may contribute to the understanding of the etiology of organofluoride-intoxication. 4. A close relationship between unconsciousness and a decrease in blood sugar levels was obtained in a MNFA (N-methyl-N-(1-naphthyl) monofluoroacetate)-intoxicated human case. Administration of large doses of glucose was found to be very effective for the recovery of unconsciousness.
発行日
1971-08-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
83巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
273
終了ページ
293
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/83/7-8/83_7-8_273/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma