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ID 31596
JaLCDOI
フルテキストURL
Thumnail fulltext.pdf 1.04 MB
著者
Miyamoto, Osamu Kagawa Medical School
Itano, Toshifumi Kagawa Medical School
Fujisawa, Mutsuo Kagawa Medical School
Tokuda, Masaaki Kagawa Medical School
Matsui, Hideki Kagawa Medical School Kaken ID publons researchmap
Nagao, Seigo Kagawa Medical School
Hatase, Osamu Kagawa Medical School
抄録

Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) were administered into the rat brain following unilateral fimbria-fornix transection. Both bFGF and NGF stimulated the sprouting of acetylcholinesterase (AChE) positive fibers in the hippocampus on the lesioned side. Furthermore, a small number of AChE-positive fibers were regenerated even when only the vehicle was administered. Rats treated with NGF as well as control group had only thin fibers, whereas those treated with bFGF had not only thin fibers but also thick fibers. These results indicate that intrinsic NGF is released and acts on damaged neurons directly, while bFGF acts them on directly and/or indirectly after brain injury.

キーワード
bFGF
NGF
regeneration
acetylcholinesterase positive fibers
sprouting
Amo Type
Article
発行日
1993-06
出版物タイトル
Acta Medica Okayama
47巻
3号
出版者
Okayama University Medical School
開始ページ
139
終了ページ
144
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT