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ID 14517
Eprint ID
14517
フルテキストURL
Thumnail 104_677.pdf 505 KB
タイトル(別表記)
The relationship between thermotolerance and changes of cell cycle after hyperthemia in culture cells
著者
松原 伸一郎 岡山大学医学部放射線医学教室
抄録
To examine the apperance of thermotolerance in a random growing population, changes in cell cycle fractions after hyperthermia, thermosensitivity and thermotolerance during the cell cycle were studied in mouse NIH3T3 cell. Progression of S phase cells was disturbed slightly and a marked increase of G(2) + M cells fraction (G(2)-block) was observed after heating (43℃ 60min, 44℃ 20min, 40min, and 45℃ 10 min). Maximun thermotolerance after 10, 20, and 30min at 45℃ appeared at 6, 12 and 45 hrs after heating, respectively. G(0) cell stimulated with frsh medium containing 10% calf serum, entered into the G(1) and S phase. When these cells were exposed to 45℃ for 30min at each point after stimulation, the thermosensitivity to heating changed with progression of time after the stimulation. S phase cells showed the highest thermosensitivity. Thermotolerance of S phase was larger than that of G(1) phase. The mechanisms involved in the appearance of thermotolerance were discussed.
キーワード
熱耐性
細胞周期
培養細胞
ハイパーサーミア
発行日
1992
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
104巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
677
終了ページ
686
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/104/5-6/104_5-6_677/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma