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ID 15993
Eprint ID
15993
フルテキストURL
Thumnail 100_763.pdf 653 KB
タイトル(別表記)
Experimental and clinical studies on the treatment of lung cancer. Part 2: Studies on brain metastases in small cell lung cancer
著者
村上 直樹 岡山大学医学部第二内科学教室
抄録
In an attempt to define the problem of brain metastases in patients with small cell lung cancer (SCLC), I analysed a series of 82 patients between 1972 and 1981. Brain metastases were documented in 10 of the 82 patients (12%) at diagnosis, and in 19 of the remaining 72 patients (26%) after onset of chemotherapy. The incidence of brain metastases developing after onset of chemotherapy was 24% (10/42) for those with limited disease, and 30% (9/30)for those with extensive disease. As for the response to chemotherapy, brain metastases were much more frequent in complete responders than in partial or non-responders; 44% for complete responders, 16% for partial responders, and 19% for non-responders. Two of the 25 complete responders relapsed in the brain 9 and 42 months, respectively, after beginning chemotherapy. They died of uncontrollable neurologic disease despite of a temporary response to brain irradiation. The probability of developing a brain metastasis increased with lengthening of patient survival to 60% after 3 years. Systemic chemotheapeutic agents with cross the blood-brain barrier appeared not to prevent the frequency of brain metastases. Althogh therapeutic irradiation for brain metastases provided adequate palliation and the majority died of systemic disease rather than neurologic disease even in complete responders, prophylactic therapy appears necessary for those who achive a complete response in order to cure SCLC.
キーワード
肺小細胞癌
脳転移
発行日
1988
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
100巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
763
終了ページ
772
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/100/7-8/100_7-8_763/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma