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ID 19471
Eprint ID
19471
フルテキストURL
Thumnail 71_2271.pdf 1.98 MB
タイトル(別表記)
Clinical and Experimental Studies on the Characteristics of Idiopathic Thrombocytopenic Purpura Part 2 The Influence of the Serum of Guinea Pigs with Experimental Thrombocytopenia on the Megakaryocyte Function
著者
本多 正憲 岡山大学医学部平木内科
抄録
With a view to study the causative factor of the experimental thrombocytopenia induced in guinea pigs by injecting anti-platelet serum into guinea pigs, the author performed the bone-marrow tissue culture of normal guinea pigs in the serum of guinea pigs with this experimental thrombocytopenia by means of the simple method of bone-marrow tissue culture, and observed the number and functions of megakaryocytes as well as the relative tissue growth rate and the wandering velocity of neutrophils. The number of megakaryocytes appearing in the tissue growth area showed no significant difference from that of the bone-marrow tissue culture in the serum of normal guinea pigs, the control, but the megakaryocyte function was markedly diminished as compared with the control, especially after 24 hours' culture no such megakaryocytes as showing the separation of platelets could at all be observed and also a marked degenerative picture was observed. The relative tissue growth rate was somewhat decreased, and the wandering velocity of neutrophils showed no significant difference from that of the control. From these findings it has become clear that in the serum of guinea pigs with experimental thrombocytopenia there exists a factor acting directly on megakarxocytes as to suppress the separation of platelets.
発行日
1959-04-15
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
71巻
5-1号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
2271
終了ページ
2281
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/71/5-1/71_5-1_2271/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma