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ID 16310
Eprint ID
16310
フルテキストURL
Thumnail 95_467.pdf 597 KB
タイトル(別表記)
Studies on a pancreatic function test utilizing the synthetic peptide BT-PABA Part I Evaluation of the diagnostic validity of PFT in comparison with ERCP or resection of the pancreas
著者
春藤 哲正 岡山大学医学部第2内科学教室
抄録
A pancreatic function test (PFT) by peroral intake of a synthetic peptide (N-benzoyl-L-tyrosyl-P-aminobenzoic acid) was performed on 29 healthy controls and 131 patients with various pancreatic diseases in order to evaluate its validity and limitations. PFT was found to be a simple and useful exocrine pancreatic function test with good reproducibility. PFT values were significantly lower in patients with noncalcified chronic pancreatitis, pancreatolithiasis, pancreatic cancer, pancreatectomy or acute pancreatitis than in healthy controls. Furthermore PFT values were abnormal in 13.6 percent of 22 patients with suspected chronic pancreatitis, 78.1 percent of 32 patients with noncalcified chronic pancreatitis, 81.5 percent of 27 patients with pancreatolithiasis and 88 percent of patients with pancreatic cancer. Mild damage of the pancreas could not be detected by PFT, though moderate to severe damage could be in most cases. As for pancreatic cancer, the PFT values were not abnormal unless the main pancreatic duct was obstructed within 6 cm of the Vaterian papilla, and as for chronic pancreatitis, values were abnormal only when dilatation of the pancreatic duct was accompanied by stenosis, irregular margin, rigidity and/or obstruction. Evaluation of patients who had undergone a pancreatectomy indicated that PFT values were abnormal when more than the proximal half or the distal three-fourths of the pancreas was resected. PFT was useful in following up recovery from acute pancreatitis. PFT is slightly less sensitive than the pancreozymin secretin test in detecting exocrine pancreatic dysfunction, and a normal PFT value does not necessarily rule out pancreatic disease.
キーワード
PFT
ERCP
膵部分切除
発行日
1983-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
467
終了ページ
476
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/5-6/95_5-6_477/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma