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ID 46848
JaLCDOI
フルテキストURL
著者
Shien, Tadahiko Department of Breast and Endocrine Surgery, Okayama University Hospital ORCID Kaken ID publons
Doihara, Hiroyoshi Department of Breast and Endocrine Surgery, Okayama University Hospital Kaken ID researchmap
Nishiyama, Keiko Department of Breast and Endocrine Surgery, Okayama University Hospital
Masuda, Hiroko Department of Breast and Endocrine Surgery, Okayama University Hospital
Nogami, Tomohiro Department of Breast and Endocrine Surgery, Okayama University Hospital
Ikeda, Hirokuni Department of Breast and Endocrine Surgery, Okayama University Hospital
Taira, Naruto Department of Breast and Endocrine Surgery, Okayama University Hospital Kaken ID
抄録
Combined low-dose therapy of oral capecitabine (Xeloda) and cyclophosphamide (XC) has been demonstrated to be useful for long-term control of lesions in patients with metastatic breast cancer (MBC) and is aimed at symptomatic alleviation and prolongation of survival. Here, a retrospective review was conducted of MBC patients administered XC at the Okayama University Hospital (OUH), to evaluate responses to XC, adverse events and time to progression (TTP). Twenty patients with MBC received XC between 2006 and 2009. With the exception of 2 elderly patients who were over the age of 70 at the initial examination, all of the patients had received prior treatment with an anthracycline and/or a taxane. No complete response (CR) cases were observed, but partial response (PR) was achieved in 6 patients (30%) and SD in 9 (45%), of whom 5 (20%) sustained SD status for >12 months. The median TTP was 6 months (range:3-27 mo.). Three patients developed Grade 3 adverse events (diarrhea, nausea and stomatitis), but no other patients developed adverse reactions causing interruption of the therapy. XC was safe even in previously treated and elderly MBC patients;moreover, it yielded remarkable clinical responses.
キーワード
metastatic breast cancer
metronomic
chemotherapy
Amo Type
Original Article
発行日
2011-08
出版物タイトル
Acta Medica Okayama
65巻
4号
出版者
Okayama University Medical School
開始ページ
231
終了ページ
237
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2011 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT