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ID 15884
Eprint ID
15884
フルテキストURL
Thumnail 99_261.pdf 3.06 MB
タイトル(別表記)
Hepatic Key Carbohydrate-metabolizing Enzymes in Benign Liver Diseases and Hepatocellular Carcinoma
著者
島村 淳之輔 岡山大学医学部第一内科学教室
抄録
Patterns of seven key carbohydrate-metabolizing enzyme activities were examined in liver tissue from 125 patients with various liver diseases. Along with the progression of chronic hepatitis to liver cirrhosis (LC), activities of high-Km hexokinase (high-Km HK), fructose-1, 6-bisphosphatase (FBPase) and glucose 6-phosphatase (G6Pase) decreased, and those of glucose 6-phosphate dehydrogenase (G6PD) and hexokinase (HK) increased. In hepatocellular carcinoma (HCC), similar alterations of these enzyme activities were observed. The extent of enzyme alteration was greatest in HCC and fetal liver, and slightly less in LC and the icteric stage of acute hepatitis. Phosphofructokinase (PFK) activity was increased in acute hepatitis, and pyruvate kinase (PK) activity was increased in HCC. Principal component analysis showed G6PD and HK to be located close to α-fetoprotein and the GOT/GPT ratio. G6Pase and FBPase were distributed symmetrically to G6PD and HK. Thus, the factor loadings effectively separated HCC from the benign liver diseases. The results indicate that the determinations of these enzyme activities are useful in the clinical assessment of the progression of liver disease, which is not revealed by routine blood chemistry.
キーワード
糖代謝律速酵素
肝疾患
肝組織
主成分分析
発行日
1987-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
261
終了ページ
272
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/3-4/99_3-4_261/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma