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ID 16006
Eprint ID
16006
フルテキストURL
Thumnail 99_1137.pdf 11.8 MB
タイトル(別表記)
Mononuclear phagocyte abnormality in sarcoidosis II. Primary cultures of sarcoid granulomas
著者
岸 俊行 岡山大学医学部第二内科学教室
抄録
In order to clarify the role of monocytes and macrophages in the formation of sarcoid granulomas, primary cultures of sarcoid tissues were initiated with biopsied specimens from patients with sarcoidosis (6 lymph nodes and one subcutaneous nodule), and compared with primary cultures of 5 lymph nodes obtained from patients with other disorders. The number of monocytes and macrophages migrating from tissue explants was larger in sarcoid tissues than in non-sarcoid tissues. In the cultures of sarcoid tissues, the monocytes and macrophages aggregated at the second week of cultures and multinucleated giant cells were observed at the third week. However, these findings were not observed in the culture of non-sarcoid tissues. At the fourth week, the aggregated macrophages and multinucleated giant cells disappeared and fibroblasts developed. The lysozyme activity of the culture medium of sarcoid tissues was higher than that of non-sarcoid tissues, but no difference was observed in angiotensin-converting enzyme activity. These results suggest that the monocytes and macrophages in sarcoid granulomas have been activated by unknown factors and may transform to epithelioid cells constituting sarcoid granulomas.
キーワード
sarcoidosis
sarcoid granuloma
culture
macrophage
発行日
1987-10-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1137
終了ページ
1149
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/9-10/99_9-10_1137/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma