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ID 16004
Eprint ID
16004
フルテキストURL
Thumnail 99_1131.pdf 339 KB
タイトル(別表記)
Mononuclear phagocyte abnormality in sarcoidosis I. Studies on superoxide production of blood monocytes in patients with sarcoidosis
著者
岸 俊行 岡山大学医学部第二内科学教室
抄録
The superoxide production of peripheral blood monocytes stimulated by concanavalin A and cytochalasin E was examined in sarcoidosis patients. The superoxide production of monocytes was significantly enhanced in sarcoidosis patients (9.8±6.4 nmol/min/10(6) cells) compared with healthy controls (6.6±3.5) (p<0.02). The levels of superoxide production were 12.4±8.7 in 14 patients with stage 1 sarcoidosis (bilateral hilar lymphadenopathy), 9.4±3.9 in 15 patients with stage 2 sarcoidosis (bilateral hilar lymphadenopathy and parenchymal involvement) and 6.1±2.6 in 4 patients with stage 3 sarcoidosis (parenchymal involvement). These levels were significantly higher in patients with stage 1 and 2 sarcoidosis than in healthy controls. The superoxide production was significantly enhanced in patients with elevated serum lysozyme activity and slightly enhanced in patients with high percentages of T-lymphocytes (over 28%) in bronchoalveolar lavage fluid. These data suggest that peripheral blood monocytes in sarcoidosis patients have been activated by unknown factors.
キーワード
superoxide
monocyte
sarcoidosis
発行日
1987-10-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1131
終了ページ
1136
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/9-10/99_9-10_1131/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma