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ID 30729
JaLCDOI
フルテキストURL
著者
Ohta, Takeyuki Okayama University
Sakaguchi, Kohsaku Okayama University
Fujiwara, Akiko Okayama University
Fujioka, Shin-ichi Okayama University
Iwasaki, Yoshiaki Okayama University ORCID Kaken ID
Makino, Yasuhiro National Hospital Organization Iwakuni Clinical Center
Araki, Yasuyuki Hiroshima City Hospital
Shiratori, Yasushi Okayama University
抄録

This study was conducted to develop a simple surrogate index comprised of routinely available laboratory tests to reflect the histological fibrosis stage. Clinical characteristics and laboratory data from 368 and 249 consecutive patients with chronic hepatitis C, a training cohort and a validation cohort, respectively, were retrospectively evaluated. Platelet (Plt) count and albumin (Alb) level contributed to the discrimination of the respective fibrosis stages. We derived the fi brosis index (FI), FI = 8.0-0.01 x Plt (10 multiply 3/microliter) - Alb (g/dl), from a multiple regression model. FI significantly correlated with the histological fibrosis stage in both the initial and validation cohort at p=0.691 and p=0.661, respectively (Spearman's rank correlation coefficient, p<0.0001). The sensitivity and positive predictive value of FI at a cutoff value < 2.10 for predicting fibrosis stage F0-1 were 66.8% and 78.8% in the initial cohort and 68.5% and 63.6% in the validation cohort, respectively. Corresponding values of FI at a cutoff value >- 3.30 for the prediction of F4 were 67.7% and 75.0% in the initial cohort and 70.8% and 81.0% in the validation cohort. The fibrosis index comprised of platelet count and albumin level reflected the histological fibrosis stage in patients with chronic hepatitis C.

キーワード
albumin level
chronic hepatitis C
fi brosis index
fi brosis stage
platelet count
Amo Type
Article
発行日
2006-04
出版物タイトル
Acta Medica Okayama
60巻
2号
出版者
Okayama University Medical School
開始ページ
77
終了ページ
84
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT