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ID 17724
Eprint ID
17724
フルテキストURL
Thumnail 81_17.pdf 3.66 MB
タイトル(別表記)
Experimental and Clinical Study on Prolonged Extracorporeal Circulation
著者
岩浅 茂夫 岡山大学医学部砂田外科教室
抄録
Effects of prolonged extracorporeal circulation lasting four hours on acid-base balance were studied on dogs. Following results were obtained. 1) High flow perfusion is superior to low flow in all aspects. 2) Low molecular weight dextran is effective to prevent peripheral intravascular pooling of blood resulting in steady venous return, to maintain high flow rate and normal blood pressure, and also to inhibit increase in excess lactate. Dilution rate ranging from 15 to 25 per cent is pertinent. 3) Correction of pH with either sodium bicarbonate or Tris-buffer is preferable to compensation by respiratory alkalosis. 4) Survival time of the experimental animals can be prologed by blood replacement with fresh blood at the termination of the perfusion. However, no experimental animals survived the experiment. The same was studied on patients who underwent open heart surgery. All survived the operation and the results were as follows. 1) The metabolic changes are most prominent immediately after the perfusion and a tendency to recover appears 3 hours after the procedure. The return to normal condition is accomplished later than 5 hours after the perfusion. 2) Recovery of the various factors concerning with the acid-base balance (pH, pCO(2), baseexcess, lactids, excess lactate) is delayed proportionately to the prolongation of the perfusion time.
発行日
1969-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
81巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
17
終了ページ
37
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/81/1-2/81_1-2_17/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma