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タイトル(別表記) What enables hibernation? : insights from a mammalian hibernator, Syrian hamster
フルテキストURL poalas_034_010.pdf
著者 山口 良文|
抄録 Hibernation is an adaptive strategy for surviving during periods with little or no food availability, by profoundly reducing the metabolic rate and the core body temperature (Tb). Mammalian hibernators store fat extensively in white adipose tissues (WATs) during pre-hibernation period to prepare for hibernation. Thus, they undergo adaptive body remodelling in autumn, the pre-hibernation period, prior to hibernation, whereas little is known about the physiological and molecular mechanisms of the pre-hibernation remodelling. Syrian hamsters (Mesocricetus auratus) are facultative hibernators that can hibernate irrespective of seasons when exposed to prolonged short photoperiod and cold ambient temperature (SD-Cold) conditions. We found that before the initiation of hibernation, the body mass of Syrian hamsters decreased below a threshold, indicating that hibernation in this species depends on body condition. Global profiling of gene expression in various tissues of animals during the pre-hibernation period and hibernation period identified adaptive changes for hibernation at molecular level. Thus, Syrian hamsters as a model animal to study hibernation provide us a unique and convenient opportunity to analyse molecular and physiological mechanisms of adaptive pre-hibernation remodelling under a laboratory condition.
備考 特別講演要旨(Summary of Special Lecture)
出版物タイトル 岡山実験動物研究会報
発行日 2018-04
34巻
出版者 岡山実験動物研究会
出版者(別表記) Okayama Association for Laboratory Animal Science
開始ページ 10
終了ページ 16
資料タイプ その他
言語 Japanese
論文のバージョン publisher
Eprints Journal Name poalas