このエントリーをはてなブックマークに追加
ID 14167
Eprint ID
14167
フルテキストURL
Thumnail 105_641.pdf 1.41 MB
タイトル(別表記)
Differrential diagnosis of thyrotoxicosis using inhibition assay of a protein present in thyroid follicular spaces
著者
山原 茂裕 岡山大学医学部第三内科学教室
抄録
The difference between stimulative and destructive thyrotoxicosis is usually identified by thyroidal uptake of radioactive iodine, but uptake is not always available. At present, there is no reliable in vitro method of differential diagnosis of thyrotoxicosis. We conducted an investigation of an in vitro method of differential diagnosis of thyrotoxicosis by inhibition assay using monoclonal antibodies that recognized an antigen (14kD) differing from thyroglobulin and thyroid peroxidase. The antigen is the soluble material present in the thyroid follicular space, and is detected by immunofluorescent study. We measured the concentration of this antigen in the sera of patients with thyroid diseases by inhibition assay. In sera from patients with destructive thyrotoxicosis, the concentration of the antigen was lower than that in sera from normal subjects and from Graves' disease patients. There was no significant difference between normal subjects and Graves' disease patients. The data suggest that measurement of the antigen in sera from patients with thyroid disease can be useful for the differential diagnosis of thyrotoxicosis.
キーワード
甲状腺中毒症
亜急性甲状腺炎
バセドウ病
モノクローナル抗体
発行日
1993
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
105巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
641
終了ページ
647
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/105/5-6/105_5-6_641/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma