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ID 40955
フルテキストURL
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タイトル(別表記)
Studies on the Process of Hemoglobin Decomposition in the Subcutaneous Tissue of Rabbit Part 1. Changes in the heme and the globin after the injection of bovine blood into the subcutaneous tissue of rabbit
著者
山本 将雄 岡山大学医学部第一内科教室
抄録
By injecting bovine blood into the subcutaneous tissue on the inner side of the rabbit femur the author studied histochmeically the Decomposition of hemoglobin-heme as well as pursued serologically changes of hemoglobin-globin; and obtained the following results. 1. When bovine blood is injected subcutaneously, the hemoglobin decomposition takes place relatively quickly outside the histiocytes. Namely, on the second day after the injection the formation of hemosiderin, on the third day of bilirubin, and on the fifth day of hematoidin cristals, on the ninthday of bilifuscin can be recognized outside the cells; and the number of these is increased on the 14th day. On the other hand, within histiocytes are formed hemosiderin granules on the fifth day, hematoidin crystals on the seventh day, and hematoidin crystals are increased in number on the 14th day. 2. The precipitation of globin in the tissue is somewhat slow on the first day of the injection, but from the second day to the 15th day the precipitation presents the value of 32, 000-fold, and this maximum has been maintained throughout the period observation. 3. Therfore, the degeneration of globin observable at the process of the hemoglobin destruction is extremely trivial yet persistent, and this fact corroborates the theory advocated by K. Kajiro et al. 4. From the fact that hemosiderin is formed from hemoglobin, and then the hematoidin (bilirubin) or billifuscin is fomed and that the antigenic value of globin in the tissue is unchanged even at the stage when hematoma has almost completely disappeared, it is believed that globin is decomposed in the course of bilirubin formation from hemoglobin and is kept in the tissue for a long period of time. Therfore, the theory that indirect bilirubin is bilirubin-globin seems to be not appropriate.
発行日
1959-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
71巻
7-1号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
3799
終了ページ
3804
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/71/7-1/71_7-1_3799/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma