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ID 16421
Eprint ID
16421
フルテキストURL
Thumnail 95_1201.pdf 339 KB
タイトル(別表記)
Studies on human peripheral monocyte-mediated cytotoxicity Part II. Monocyte-mediated cytolysis in malignant cell
著者
山下 二郎 岡山大学第2内科学教室
抄録
The human peripheral monocyte-mediated cytolytic acitivity against tumor cells derived from human squamous cell-type lung cancer was measured in 16 healthy donors, 24 patients with bronchogenic carcinoma, 6 patients with malignant lymphoma and 8 patients with sarcoidosis. The activity was significantly depressed in patients with bronchogenic carcinoma (p<0.05) and in patients with malignant lymphoma (p<0.01). However, there was no significant difference between normal controls and patients with sarcoidosis. There was no significant difference monocyte-mediated cytolytic activities according to clinical stage and histologic type in lung cancer patients. A statistically significant positive correlation between phogocytic acitivity and cytolytic activity of monocytes, between monocyte-mediated cytolytic activity and cytostatic activity was observed in lung cancer patients. The data suggest that monocyte-mediated cytolytic activity in tumor bearing hosts is suppressed, and this lower activity effects the immunological surveillance and host defence mechanism against malignant tumors.
キーワード
肺癌
単球
腫瘍細胞溶解作用
発行日
1983-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1201
終了ページ
1207
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/11-12/95_11-12_1201/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma