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ID 16420
Eprint ID
16420
フルテキストURL
Thumnail 95_1193.pdf 1.14 MB
タイトル(別表記)
Studies on human peripheral monocyte-mediated cytotoxicity Part I. Monocyte-mediated cytostasis in malignant cells
著者
山下 二郎 岡山大学第2内科学教室
抄録
The monocyte-mediated cytostatic acitivity against human tumor cells was measured in healthy donors and patients with bronchogenic carcinoma, malignant lymphoma, sarcoidosis and pulmonary tuberculosis. The target cells employed were HeLa cells and squamous cell-type lung cancer derived EBC-1 cells. Cytostatic activity was measured by inhibition of (3)H-thymidine uptake by target cells. The mean value of monocyte-mediated cytostasis in HeLa cells was 46.4±11.8% in 18 healthy donors, 47.7±19.0% in 31 patients with bronchogenic carcinoma, 39.9±21.7% in 19 patients with malignant lymphoma, 46.2±17.7% in 14 patients with sarcoidosis, and 48.6±15.7% in 9 patients with pulmonary tuberculosis. The mean value of monocyte-mediated cytostasis in EBC-1 cells was 87.4±8.5 % in 18 healthy donors, 78.9±16.8% in 39 patients with bronchogenic carcinoma, 82.5±15.1% in 25 patients with malignant lymphoma, 87.0±6.7% in 16 patients with sarcoidosis, and 94.3±8.8% in 8 patients with pulmonary tuberculosis. No significant difference between healthy donors and patients with the above mentioned disorders was observed in the HeLa cell assay. But there were remarkably low activities, two standard deviations below the mean value of healthy donors, in 30% of the patients with bronchogenic carcinoma and 14% of the patients with malignant lymphoma in the EBC-1 cell assay. In lung cancer patients no significant positive correlation was observed between monocyte-mediated cytostatic acitivity and other monocyte functions. The data suggest that the tumor cell killing activity of peripheral monocytes was decreased in patients with malignant neoplasma.
キーワード
肺癌
単球
腫瘍細胞増殖抑制
発行日
1983-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
95巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1193
終了ページ
1200
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/95/11-12/95_11-12_1193/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma