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ID 17174
Eprint ID
17174
フルテキストURL
Thumnail 92_1217.pdf 886 KB
タイトル(別表記)
Platelet monoamine oxidase activity in schizophrenics -Kinetic aspects-
著者
小出 やよい 岡山大学医学部脳代謝研究施設病態生化学部門
抄録
The present study was undertaken to study the relationship between changes in platelet monoamine oxidase (MAO) activity and schizophrenia. In addition, some biochemical characteristics of human platelet MAO were examined. The results are as follows; 1) There was no evidence to suggest that differences in methods used in the determination of platelet MAO activity caused the conflicting results in the literature. 2) It was confirmed from a kinetic study that MAO reaction in platelets proceeded via a ping-pong mechanism as previously reported in brain and liver. 3) The frequency distribution for the Michaelis constant (Km) and maximal velocity (Vmax) in apparently healthy subjects exhibited a skewed unimodal pattern. The mean of the Vmax value for females was significantly higher than the corresponding value for males. 4) Platelet MAO activity was determined in 8 schizophrenics and non-schizophrenic members from a North-Swedish pedigree with a high frequency of schizophrenia. There were no statistically significant differeneces in apparent Km and Vmax values between schizophrenics and their non-schizophrenic relatives, although a tendency to lowered Vmax and increased Km values was observed among the schizophrenic subjects. 5) MAO activity was assayed in platelets from 22 (8 monozygotic and 14 dizygotic) twin pairs. At least one twin (proband) of each pair suffered from serious psychiatric disorders including schizophrenia. The correlation between proband and control twins was high for both apparent Km and Vmax. No differences in kinetic properties were found between schizophrenic and non-schizophrenic twins. The monozygotic twin pairs showed very high correlations (Km; r=0.93, Vmax; r=0.86) as compared to dizygotic twins (Km; r=0.81, Vmax; r=0.50) and apparently healthy subjects (Km; r=0.46, Vmax; r=0.33).
キーワード
platelet monoamine oxidase
schizophrenic family
twin
Michaelis constant
maximal velocity
発行日
1980-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
92巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1217
終了ページ
1232
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/92/11-12/92_11-12_1217/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma