このエントリーをはてなブックマークに追加
ID 13774
Eprint ID
13774
フルテキストURL
Thumnail 106_763.pdf 1.35 MB
タイトル(別表記)
Natural cytotoxicity against isolated epithelial cells of rat small intestine
著者
富岡 憲明 岡山大学医学部第一外科学教室
抄録
The natural cytotoxicity against isolated epithelial cells of rat small intestine was studied. The isolation of intestinal epithelial cells was easily performed using EDTA and DTT digestion with good viability. The cells were labelled by 51Cr sufficiently to be usable for the in vitro 51Cr release assay. The cytotoxic activity of spleen cells to syngeneic and allogeneic epithelial cells was 13.5% and 13.7%, respectively. Cold inhibition assays revealed that the susceptibility of isolated epithelial cells to killing is non-specific for lineage and no restriction with major histocompatibility complexes was noticed. These findings correspond to the cytotoxicity against skin epidermal cells, in which skin cells are killed by normal spleen cells by natural killer systems. Therefore, the isolated epithelial cells of rat small intestine can become the target of natural killer cells, suggesting that rapidly differentiating cells may be controlled by natural killer systems.
キーワード
isolated epithelial cells
rat small intestine
natural cytotoxicity
NK susceptibility
備考
原著
発行日
1994-08
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
106巻
7-8号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
763
終了ページ
769
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/106/7-8/106_7-8_763/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma