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ID 47111
フルテキストURL
著者
Mimura, Yukari Division of Developmental Studies and Support, Okayama University Graduate School of Education
Ogura, Toshio Health and Medical Center, Okayama University
Otsuka, Fumio Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences ORCID Kaken ID
抄録
Thyroid stimulating hormone receptor antibody (TRAb) plays an important role in Graves' disease (GD). A second-generation measurement system has been developed and we have gotten a benefit by the system clinically. In this study, we determined 4 kinds of TRAb in 42 GD patients using the current and second-generation measurement systems to investigate the differences between them. The secondgeneration measurement system exhibited higher positive rates and inhibition rates of thyroid stimulating hormone (TSH) binding than those of the current system. Furthermore, 42 patients with GD were classified into 4 groups by GD activity. The actual values of all TRAbs and positive rates exhibited a tendency to increase significantly with GD activity. Of significance, 2 TRAbs in the second-generation measurement system exhibited high positive rates. However, all actual values of patients did not necessarily agree with these tendencies. The values of TRAb-human detecting anti-human TSH receptors at an approximate cut-off value reflected GD activity more accurately than those of TRAb-CT detecting anti-porcine TSH receptor. This suggests the possibility of specific differences between TSH receptors and further studies are required to further examine these effects.
キーワード
Graves' disease
human-TRAb
TSAb
発行日
2011-06-25
出版物タイトル
岡山大学大学院教育学研究科研究集録
出版物タイトル(別表記)
Bulletin of Graduate School of Education, Okayama University
147巻
出版者
岡山大学大学院教育学研究科
出版者(別表記)
Graduate School of Education, Okayama University
開始ページ
135
終了ページ
144
ISSN
1883-2423
NCID
AA12338258
資料タイプ
紀要論文
言語
English
論文のバージョン
publisher
査読
無し
Eprints Journal Name
bgeou