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ID 30375
JaLCDOI
フルテキストURL
著者
Mimura, Yukari Okayama University
Ogura, Toshio Okayama University
Yamauchi, Takayoshi Okayama University
Otsuka, Fumio Okayama University Kaken ID
Oishi, Tetsuya Okayama University
Harada, Kazushi Okayama University
Hashimoto, Masami Okayama University
Ota, Zensuke Okayama University
抄録

We recently reported that stimulation of the arginine vasopressin (AVP) V1-receptor enhanced the pressor response in spontaneously hypertensive rats (SHR). In the present study, we investigated acute changes in systolic blood pressure (SBP) and heart rate (HR) after intravenous injections of AVP, OPC-21268 (a V1-receptor antagonist), and OPC-31260 (a V2-receptor antagonist), in anesthetized DOCA-salt hypertensive rats (DOCA) and age-matched sham-operated Wistar rats (control) to determine whether the pressor effect is specific to SHR or is present in other hypertensive animal models. SBP increased significantly in DOCA rats 9 min after injection of AVP 5 ng/kg without a concomitant increase in HR. Neither OPC-21268 3mg/kg nor OPC-31260 3mg/kg caused significant changes in SBP or HR. SBP tended to increase when AVP was administered after injection of OPC-31260. HR increased significantly 15 min after the combined treatment with OPC-31260 and AVP in DOCA rats compared with control rats. SBP did not change significantly when AVP was administered after injection of OPC-21268 in DOCA or control rats, but HR decreased significantly from 1 to 4 min after injection of AVP in DOCA rats. Our results suggest that V1-receptor stimulation does not enhance the pressor response in the DOCA rat, which is a model of volume-dependent hypertension, suggesting that the AVP system, especially V1-receptor, is not as important in the development or maintenance of hypertension in DOCA rats as in SHR.

キーワード
vasopressin
DOCA-salt hypertensive rat
V1-and V2-receptor antagonist
spontaneously hypertesive rat(SHR)
OPC-21268
Amo Type
Article
発行日
1995-08
出版物タイトル
Acta Medica Okayama
49巻
4号
出版者
Okayama University Medical School
開始ページ
187
終了ページ
194
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT