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ID 16820
Eprint ID
16820
フルテキストURL
Thumnail 91_355.pdf 2.55 MB
タイトル(別表記)
Effects of extracorporeal circulation on myocardial metabolism and postoperative cardiac function
著者
原 浩平 岡山大学医学部第二外科教室
抄録
The experiment was carried out to investigate myocardial metabolism during extracorporeal circulation (ECC) and cardiac function following open heart surgery. Myocardial changes were assessed by measuring the levels of cyclic AMP, ATP, lactate and pyruvate in the right atrial myocardium and coronary blood. Myocardial cyclic AMP and ATP decreased significantly during ECC, although they remained with moderate hypothermia. The level of lactate in the myocardium rose in all cases. There was no significant correlation between ECC time and hypothermia. Serum lactate was elevated at the beginning of ECC and increased progressively during ECC, but the coronary A-V difference of lactate (⊿L) remained unchanged. The serum pyruvate level increased moderately during ECC but its A-V difference did not vary. The data suggest that lactate and pyruvate were taken up by the myocardium. There was a significant inverse correlation between cardiac index and ECC time at 2, 4 and 6 hours after operation. Stroke index showed attitude similar to cardiac index. There was a significant positive correlation between total peripheral vascular resistance and ECC time. The cardiac index and total peripheral vascular resistance with hypothermia were significantly better than those with normothermia. Patients with higher myocardial cyclic AMP and ATP at the end of ECC had better cardiac indices at 2 and 6 hours after open heart surgery.
キーワード
体外循環
開心術後心機能
心筋代謝
サイクリックAMP
ATP
発行日
1979-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
91巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
355
終了ページ
378
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/91/3-4/91_3-4_355/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma