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ID 32878
JaLCDOI
フルテキストURL
著者
Ebara, Shin Okayama University
Manabe, Daisuke Okayama University
Kobayashi, Yasuyuki Okayama University Kaken ID
Tanimoto, Ryuta Okayama University
Saika, Takashi Okayama University
Nasu, Yasutomo Okayama University Kaken ID researchmap
Saito, Shirou National Hospital Organization Tokyo Medical Center
Satoh, Takefumi Kitasato University School of Medicine
Miki, Kenta Jikei University School of Medicine
Hashine, Katsuyoshi National Hospital Organization Shikoku Cancer Center
Kumon, Hiromi Okayama University
抄録

From September 2003 to December 2005, 188 patients who visited our hospital and allied institutions for the purpose of prostate brachytherapy were administrated hormonal therapy for volume reductions before brachytherapy. The pretreatment and posttreatment of prostate volume using a transrectal ultrasound volumetric study and the types and duration of hormonal therapy were analyzed. We administered 91 patients with Luteinizing hormone-releasing hormone (LH-RH) agonist, 49 patients with anti-androgen (bicaltamide/flutamide), and 48 patients with maximum androgen blockade (MAB). The duration of the hormonal therapy was 1-3 months for 49 patients, 4-6 months for 59 patients, 7-9 months for 40 patients, 10-12 months for 32 patients, and over 13 months for 8 patients. Before the initiation of hormonal therapy, the mean prostate volume was 35.12 ml (11.04-78.71 ml), and the average of prostate volume before and after hormonal therapy was 36.79 ml and 24.79 ml, respectively (a 32.4% reduction). The prostate volume reduction rate was 32.0% for the LH-RH agonist only, 18.1% for the anti-androgen only and 41.2% for the MAB. No statistically significant difference was observed for the duration of hormonal therapy between 3 groups. A three-month course of the neoadjuvant LH-RH agonist indicated a sufficient volume reduction effectiveness for a large prostate volume.

キーワード
androgen deprivation therapy
brachytherapy
localized prostate cancer
prostate volume reduction
Amo Type
Original Article
発行日
2007-12
出版物タイトル
Acta Medica Okayama
61巻
6号
出版者
Okayama University Medical School
開始ページ
335
終了ページ
340
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT