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ID 31973
JaLCDOI
フルテキストURL
著者
Edamura, Kohei Okayama University
Saika, Takashi Okayama University
Senoh, Takashi Okayama University
Koizumi, Fumihito Okayama University
Manabe, Daisuke Okayama University
Ebara, Shin Okayama University
Kaku, Haruki Okayama University
Yokoyama, Teruhiko Okayama University
Abarzua, Fernando Okayama University
Nagai, Atsushi Okayama University
Nasu, Yasutomo Okayama University Kaken ID researchmap
Tsushima, Tomoyasu Okayama University
Kumon, Hiromi Okayama University
抄録

This study was undertaken to reveal the trends of prostate cancer and the outcome of treatment modalities for each disease stage in patients in a single institute over a 10-year period. From January 1994 through December 2003, 420 consecutive patients with previously untreated and histologically confirmed prostate cancer were analyzed for annual distributions of disease stages and treatment modalities and for long-term clinical progression-free survival, prostate cancer-specific survival, and prostate-specific antigen (PSA) failure-free survival rates for each stage and treatment modality. Annual trends showed that the number of patients, especially those with clinically localized cancer, increased dramatically. The 5-year disease-specific survival rates for patients with clinically localized disease were 100 percent for all treatment modalities, including hormonal therapy alone. Patients with PSA levels less than 10 ng/ml showed an 81 percent 5-year PSA failure-free survival rate with radical prostatectomy. Stage C patients treated by surgery or radiation-based therapy with concomitant hormonal therapy obtained 93 percent and 100 percent cause-specific survival rates, respectively, and those treated by hormonal therapy alone showed a 79 percent rate. The number of patients with localized prostate cancer was increasing in this decade. While long-term hormonal therapy alone was highly efficient in controlling localized prostate cancer, radical therapies in conjunction with neo-adjuvant hormonal therapy produced better survival rates in cases of locally advanced disease.

キーワード
prostate carcinoma
long-term
cohort
retrospective
outcome
Amo Type
Article
発行日
2005-10
出版物タイトル
Acta Medica Okayama
59巻
5号
出版者
Okayama University Medical School
開始ページ
195
終了ページ
199
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT