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ID 15899
Eprint ID
15899
フルテキストURL
Thumnail 99_375.pdf 1020 KB
タイトル(別表記)
Endocrinological study of aortitis syndrome, with enphasis on the adrenal system and the renin-angiotensin-aldosterone system
著者
今吉 英介 岡山大学医学部第二外科学教室
抄録
Blood level of nine hormones and one enzyme were measured in twelve patients with the aortitis syndrome and in seven normal women in order to analyze the endocrinological environment of the aortitis syndrome. The hormones and enzyme measured were: pituitary system: TSH, ACTH; adrenal cortex: dehydroepiandrosterone-sulfate (DHEA-S); adrenal medulla: adoenaline (AD); sympathetic system: noradrenaline (NA); renin-angiotensin-aldosterone system (RAA): plasma renin activity (PRA), angiotensin- I (AT I), angiotensin- II (AT II), angiotensin converting enzyme (ACE), aldosterone (ald). The insulin-induced hypoglycemic stress test was introduced to further evaluate TSH, ACTH, DHEA-S, AD and NA. The hypoglycemic stress test revealed decreased reaction of the pituitary gland, adrenal cortex, adrenal medulla and sympathetic system in the patients with the aortitis syndrome. The RAA system showed unique results. The first half of the system was remarkably exaggerated, although the second half remained inappropriately in the normal range. These results suggest that the patients with the aortitis syndrome were in a state of hyperreninemic hypoaldosteronism with a shift of hormonal metabolism in the adrenal cortex. Discriminant analysis proved the most important hormones unique to the aortitis syndrome to be AD, DHEA-S and PRA. We concluded that the endocrinological changes seen in patients with the aortitis syndrome were a remarkable increase in PRA superimposed by hyperreninemic hypoaldosteronism, impaired function of the adrenal cortex associated with metabolic shift and markedly diminished function of the adrenal medulla.
キーワード
大動脈炎症候群
内分泌機能
インスリン誘発低血糖負荷試験
副腎機能
レニン・アンギオテンシン・アルドステロン系
発行日
1987-04-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
99巻
3-4号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
375
終了ページ
387
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/99/3-4/99_3-4_375/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma