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ID 16964
Eprint ID
16964
フルテキストURL
Thumnail 94_1095.pdf 3.17 MB
タイトル(別表記)
Histogenesis of pancreatic carcinoma induced by diisopropanolnitrosamine in Hamsters
著者
中島 晃 岡山大学医学部第1外科
抄録
Histogenesis of experimental pancreatic carcinoma induced by DIPN in hamsters was studied morphologically and histologically. On the basis of carcinogenesis, two stages of changes in pancreatic tissue were seen: one being edematous which peaked at 8-10 weeks and the other being storomalfibrotic with acinous atrophy, resembling chronic pancreatitis. Hyperplastic changes (papillary hyperplasia and ductal proliferation) developed in the former stage, and atypical duct and adenomatous lesions (intraductal, tubular, papillary cystic and multilocular adenoma) were seen in the latter stage. In view of the histological resemblance of the stages, it was thought that hyperplastic changes develop into adenomatous lesions gradually. Pancreatic carcinomas, all of ductal origin, were seen at 16 weeks and after. Metastasis in regional lymph nodes and invasion of lymph and blood vessels were observed. According to the size of tumors and existence of infiltration, carcinomas were classified as infiltrated, minute and in situ carcinomas. Because of the similarity in the histological features, it was suggested that adenomas became infiltrated carcinomas, and intraductal adenomas or atypical ducts were the source of in situ carcinomas. However, minute carcinomas, in the absence of a precancerous lesion, were thought to be de novo in origin.
キーワード
DIPN
ductal proliferation
adenoma
atypical duct
de novo
発行日
1982-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
94巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1095
終了ページ
1111
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/94/11-12/94_11-12_1095/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma