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ID 17896
Eprint ID
17896
フルテキストURL
Thumnail 81_601.pdf 1.11 MB
タイトル(別表記)
Experimental Study on the Oral Gangrene Appearing in Takahara's Disease Part Ⅰ Histopathological Study on Palate of Duck after Injection of Diplococcus pneumoniae (Type Ⅱ)
著者
三谷 恭夫 岡山大学医学部耳鼻咽喉科学教室
抄録
In acatalasemia we often encounter specific oral gangrene called Takahara's disease. With the purpose to elucidate the causative factor of this gangrene, ducks having only a trace amount of catalase in their blood or plalate tissue were used as experimental animals. Diplococcus pneumoniae (Type Ⅱ) is known to generate hydrogen peroxide and contains little or no catalatic substance in itself. By suspending this Diplococcus pneumoniae in isotonic saline solution of 0.75% glucose, this suspension was injected under the mucous membrane of the duck palate. Then histopathological investigations and macroscopical observations were carried out at certain intervals after the injection. The results obtained were as follows. 1) Macroscopically, 24 hours after injection there appeared whitish coat and slight reddening and swelling surrounding the coat, and 72 hours after injection gangrene resembling the one observable in acatalasemia cases appeared. 2) Experimental histopathological study showed marked changes in blood vessel wall, In contrast, pathological changes of muscles and glands were hardly observed. Now we hold such hypotheses proposed by Kaziro or Takahara that dysfunction of the so-called respiratory enzyme group or oxygen deficiency due to methemoglobin-formation are the causative factors of this disease. From these results, it is assumed that the macroscopical and histopathological changes in duck palate resembling the findings observed in acatalasemia cases were caused by the oxidative action of deposit of hydrogen peroxide generated by Diplococcus pneumoniae (Type Ⅱ). The action mechanism of hydrogen peroxide is not definitively clarified from these results. But it is certain that the circulatory disturbances brought about by the marked changes in blood vessel wall, especially the wall of arteries, seem to evoke definitively oral gangrene.
発行日
1970-03-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
81巻
9-10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
601
終了ページ
608
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/81/9-10/81_9-10_601/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma