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ID 18492
Eprint ID
18492
フルテキストURL
Thumnail 75_213.pdf 14.2 MB
タイトル(別表記)
Studies on the Cell-free Transmission of X-ray and 20-Methylcholanthrene-induced RF Mouse Leukemia
著者
入野 昭三 岡山大学医学部平木内科教室
太田 善介 岡山大学医学部平木内科教室
岡田 耕一 岡山大学医学部平木内科教室
三好 勇夫 岡山大学医学部平木内科教室
瀬崎 達雄 岡山大学医学部平木内科教室
川村 範夫 岡山大学医学部平木内科教室
国定 岑生 岡山大学医学部平木内科教室
池尻 孝治 岡山大学医学部平木内科教室
佐藤 昌信 岡山大学医学部平木内科教室
宗田 範 岡山大学医学部平木内科教室
須崎 正則 岡山大学医学部平木内科教室
抄録
Incidence of leukemia in RF mice exposed to a single whole body irradiation of 350 r X-rays was 77.4%, 41 out of 53 animals. Of them, 20 developed the thymic and other 20 the non-thymic lymphocytic leukemia, while only one developed myelogenous leukemia. Incidence of leukemia by 20-methylcholanthrene painting was 88%, 22 out of 25 animals. Of them, 12 developed lymphocytic leukemia and other 10 myelogenous leukemia. Experiments of inoculating cell-free filtrate prepared from these X-ray and 20-methylcholanthrene-induced leukemic RF mice revealed the following facts. 1) Cell-free filtrates from the leukemic mice which were induced by a single whole body X-irradiation were inoculated to the newborn mice of the same strain less than 16 hours old. Two (16.7%) of the twelve incculated animals developed leukemia 357 th and 374 th days, respectively, after the inoculation. Inoculation of the cell-free filtrates from normal mice to the newborn mice of the same strain did not produce leukemia. 2) Attempts to inoculate cell-free filtrate from 20-methylcholanthrene-indeced leukemic RF mice to newborn mice of the same strain were successful. 3) Cell-free filtrate from myelogenous leukemic mouse caused lymphocytic leukemia in one of three inoculated mice. This is suggestive of the possibility of transformation of the type of leukemia during cell-free transmission. 4) Intracerebral inoculation of cell-free filtrate from the brain of a mouse with lymphocytic leukemia also produced lymphocytic leukemia in one of two inoculated mice. 5) Inoculation of cell-free filtrate from the leukemic mice developed mammary carcinoma in one of three inoculated female mice. 6) Serial cell-free passage in two generations of 20-methylcholanthrene-induced leukemic mouse was possible. One of two inoculated mice developed leukemia in the first transmission and one of eight inoculated mice in the second transmission. 7) Only two cases of spontaneous lymphocytic leukemia were observed in RF mice during the past four years and the cell-free transmission of one leukemic mouse was also successful. 8) Virus-like particles were demonstrated by electron microscope in the lymph nodes of 20-methylcholanthrene-induced leukemic mouse. These facts suggest that the X-ray and chemical carcinogens may act to induce leukemia or mammary carcinoma by the "activation" of a latent virus naturally resident in the RF mouse.
発行日
1963-03-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
75巻
1-3号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
213
終了ページ
231
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/75/1-3/75_1-3_213/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma