REPO

岡大三朝医療センター研究報告 69巻
1998-12 発行

The clinical effects of dietary supplementation with n-3 fatty acids in bronchial asthma compared with n-6 fatty acids.

岡本 誠 岡山大学医学部附属病院三朝分院内科
芦田 耕三 岡山大学医学部附属病院三朝分院内科 Kaken ID researchmap
光延 文裕 岡山大学医学部附属病院三朝分院内科 Kaken ID publons researchmap
御舩 尚志 岡山大学医学部附属病院三朝分院内科
保崎 泰弘 岡山大学医学部附属病院三朝分院内科
柘野 浩史 岡山大学医学部附属病院三朝分院内科
原田 誠之 岡山大学医学部附属病院三朝分院内科
湯本 英一朗 岡山大学医学部附属病院三朝分院内科
高田 真吾 岡山大学医学部附属病院三朝分院内科 Kaken ID publons
谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
片岡 幹男 岡山大学医学部第二外科 Kaken ID researchmap
原田 実根 岡山大学医学部第二外科
Publication Date
1998-12
Abstract
N-3 fatty acids, such as fish oil, have been reported to have some beneficial effects in patients with bronchial asthma by suppressing leukocyte function, followed by reduction of the need for pharmacologic agents. To examine the effects of dietary supplementation with perilla seed oil rich in α-linolenic acid (ALA), 23 patients with asthma took corn oil rich in linoleic acid (LA) for the former two weeks, perilla seed oil for the later two weeks. The asthmatic patients were classified into two groups by the changes of the generation of leukotrienes B4 (LTB4), C4 (LTC4), and B5 (LTB5) during the two courses of dietary modification: one was sensitive to dietary modification, and the other was insensitive to dietary supplementation. We compared the two groups in clinical characteristics. Significant differences were observed in peak flow (PEF), forced expiratory volume in one second (FEV1.0), IgE, sex, obesity index (OI), concentration of serum total cholesterol, albumin, low density lipoprotein {LDL)-cholesterol, β-lipoprotein and phospholipids between two groups. This study indicated that these factors influence the generation of LTB4, C4 and B5 of asthmatic patients in dietary supplementation.
Keywords
n-3系脂肪酸 (n-3 fatty acids)
エゴマ油 (perilla seed oil)
気管支喘息 (bronchial asthma)
LTB4
LTC4
ISSN
0918-7839
NCID
AN10430852
NAID