REPO

岡大三朝医療センター研究報告 69巻
1998-12 発行

Association of the mean CT number by high resolution computed tomography (HRCT) with generation of leukotrienes B4 (LTB4) and C4 (LTC4) in patients with pulmonary emphysema

光延 文裕 岡山大学医学部附属病院三朝分院内科 Kaken ID publons researchmap
御舩 尚志 岡山大学医学部附属病院三朝分院内科
保崎 泰弘 岡山大学医学部附属病院三朝分院内科
芦田 耕三 岡山大学医学部附属病院三朝分院内科 Kaken ID researchmap
柘野 浩史 岡山大学医学部附属病院三朝分院内科
岡本 誠 岡山大学医学部附属病院三朝分院内科
原田 誠之 岡山大学医学部附属病院三朝分院内科
湯本 英一郎 岡山大学医学部附属病院三朝分院内科
高田 真吾 岡山大学医学部附属病院三朝分院内科 Kaken ID publons
越智 浩二 岡山大学医学部臨床検査医学
原田 英雄 岡山大学医学部臨床検査医学
長谷川 晴巳 鳥取市立病院内科
Publication Date
1998-12
Abstract
The generation of leukotrienes B4 (LTB4) and C4 (LTC4) by peripheral leukocytes stimulated with Ca ionophore A23187 was examined in 17 patients with pulmonary emphysema. They were divided into three groups according to the mean CT number; A (<-940 HU), B (-940 ≦, <-930 HU), and C (-930 HU ≦ ).1. The values of FVC (% predicted), FEV1.0% and DLco (% predicted) showed a tendency to decrease as the mean CT number was smaller. The value of % FVC was significantly lower in patients with group A than in those with group C (p<0.05). 2. The generation of both LTB4 and LTC4 was significantly higher in patients with emphysema compared to the generation in healthy subjects (LTB4;p<0.05, LTC4;P<0.05). 3. The generation of LTB4 and LTC4 in patients with emphysema was higher as the mean CT number was larger (severity of the disease become less). The LTC4 production was significantly higher in patients with group C(mild or moderate type of emphysema) than in those with group A(advanced type of emphysema). These results suggest that the generation of LTB4 and LTC4 is higher in patients with mild or moderate type of emphysema than in those with advanced type of the disease.
Keywords
emphysema
mean CT number
LTB4
LTC4
ISSN
0918-7839
NCID
AN10430852
NAID