REPO

岡大三朝医療センター研究報告 66巻
1995-09 発行

Experimental model of chronic pancreatitis, a review - Does it really exist?

Chowdhury Riaz 岡山大学臨床検査医学
越智 浩二 岡山大学臨床検査医学
原田 英雄 岡山大学臨床検査医学
田中 淳太郎 岡山大学臨床検査医学
水島 孝明 岡山大学第2内科 Kaken ID researchmap
松本 秀次 岡山大学臨床検査医学
妹尾 敏伸 岡山大学臨床検査医学
一村 光子 岡山大学臨床検査医学
穐山 恒雄 岡山大学臨床検査医学
横田 聡 岡山大学三朝分院
Publication Date
1995-09
Abstract
Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress.
ISSN
0918-7839
NCID
AN10430852
NAID