Chowdhury Riaz
岡山大学臨床検査医学
越智 浩二
岡山大学臨床検査医学
原田 英雄
岡山大学臨床検査医学
田中 淳太郎
岡山大学臨床検査医学
松本 秀次
岡山大学臨床検査医学
妹尾 敏伸
岡山大学臨床検査医学
一村 光子
岡山大学臨床検査医学
穐山 恒雄
岡山大学臨床検査医学
横田 聡
岡山大学三朝分院
Experimental model of pancreatitis is mandatory for elucidating the pathobiology of the disease and also to see the response of a novel treatment. In addition, the need for an animal model of chronic pancreatitis is further strengthened by the relative inaccessibility and paucity of the human pancreatitis tissue. Whereas various models of acute pancreatitis and also of exocrine pancreatic tumor have been described, chronic pancr-eatitis has not been consistently reproduced in experimental animals. Many researchers attempted to establish an experimental model of chronic pancreatitis either by partially obstructing the drainage of pancreatic secretion in dogs and cats or by feeding alcohol to dogs and rats with and without temporary occlusion of the biliopancreatic duct or by surgically inducing ischaemia in the pancreas of the dogs. But, none of these models is identical with human disease. A consistently reproducible model of human chronic pancr-eatitis probably does not exist. In this expanding era of molecular biology which promises us to enhance greatly our understanding of this disease, a right experimental model of chronic pancreatitis is still in progress.