REPO

岡大三朝医療センター研究報告 66巻
1995-09 発行

Release of histamine and leukotriene C4 from bronchoalveolar cells in patients with bronchial asthma. A role of histamine in atopic asthma.

光延 文裕 岡山大学医学部附属病院三朝分院内科 Kaken ID publons researchmap
御舩 尚志 岡山大学医学部附属病院三朝分院内科
梶本 和宏 岡山大学医学部附属病院三朝分院内科
保﨑 泰弘 岡山大学医学部附属病院三朝分院内科
横田 聡 岡山大学医学部附属病院三朝分院内科
谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
越智 浩二 岡山大学医学部附属病院臨床検査医学
原田 英雄 岡山大学医学部附属病院臨床検査医学
Publication Date
1995-09
Abstract
To clarify the main humoral triggering factor (histamine and/or leukotriene) of the early stage of asthma attacks, the release of histamine and leukotriene C4 (LTC4) from bronchoalveolar lavage (BAL) cells stimulated with Ca ionophore A23187 was examined in 7 patients with atopic asthma, and the results were compared to those in 7 nonatopic asthma patients. 1. The proportion of BAL basophilic cells was significantly higher in atopic patients than in nonatopic patients (p<0.05). 2. The content of histamine in BAL fluid was significantly higher in atopic (2.3mcg/mℓ) comparted to that in nonatopic patients (0mcg/mℓ)(p<0.001). The content of LTC4 was high in nonatopic (2.4ng/mℓ) than in atopic patients (0.5ng/ mℓ), however, this was not significant. 3. The release of histamine from BAL cells was 32.6% in atopic and 0% in nonatopic patients, and this was significant (p<0.001). The release of LTC4 from BAL cells was significantly higher in nonatopic (11.3ng/10(6)cell) than in atopic (3.5ng/10(6)cell)(p<0.02). The results demonstrate that histamine play more important role in atopic patients as a main triggering factor of attacks than LTC4. In contrast, in nonatopic patients, LTC4 is more predominant than histamine during early stage of asthma attacks.
Keywords
Histamine
LTC4
BAL cells
atopic asthma
ISSN
0918-7839
NCID
AN10430852
NAID