Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Characteristics of humoral and cellular factors participating in onset mechanism of asthma in relation to clinical types classified by symptoms.

谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
貴谷 光 岡山大学医学部附属病院三朝分院内科
御船 尚志 岡山大学医学部附属病院三朝分院内科
光延 文裕 岡山大学医学部附属病院三朝分院内科
梶本 和宏 岡山大学医学部附属病院三朝分院内科
杉本 啓介 岡山大学医学部附属病院三朝分院内科
横田 聡 岡山大学医学部附属病院三朝分院内科
平松 順一 岡山大学医学部附属病院三朝分院内科
瓦屋 正志 岡山大学医学部附属病院三朝分院内科
中桐 善康 岡山大学医学部附属病院三朝分院産婦人科
多田 慎也 岡山大学医学部第2内科
木村 郁郎 岡山大学医学部第2内科
抄録
Characteristics of each asthma type classified by clinical symptoms and findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types.
キーワード
Bronchial asthma
Asthma classification
BAL fluid
chemical mediators
ISSN
0918-7839
NCID
AN10430852