Published by Misasa Medical Center, Okayama University Medical School
Published by Misasa Medical Center, Okayama University Medical School

<Formerly known as>
岡大三朝分院研究報告 (63号-72号) 環境病態研報告 (57号-62号)
岡山大学温泉研究所報告 (5号-56号) 放射能泉研究所報告 (1号-4号)

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Basophil response to antigen and anti-IgE. 2. Morphological changes in secretory process

谷崎 勝朗 岡山大学医学部附属病院三朝分院内科
高橋 清 岡山大学医学部第二内科
木村 郁郎 岡山大学医学部第二内科
Morphological changes of blood basophils activated by antigen and anti-IgE were discussed in relation to release mechanisms of the cells. 1. Basophils activated by antigen and anti-IgE show two different types : A form (pear-shaped) and B from (swollen type), on smear preparartions. 2. Pear-shaped basophils(reactive basophils), which appear after stimulation by antigen and anti-IgE, can be observed by the staining solution for the direct count of basophils and eosinophils. 3. The incidence of reactive basophils increases after addition of antigen. Thus, observation of reactive basophils can be clinically applied for detecting allergen (DCRB ; direct connt of reactive basophils). 4. Observation of morphological basophil response by phase- contrast microscopic motion pictures demonstrates that basophils activated by antigen show two different reponses, increase in motility (oriented movement) and degranulation.
morphological changes of basophils (好塩基球の形態的変化)
reactive basophils (反応好塩基球)
degranulation (脱顆粒)
histamine release (ヒスタミン遊離)